UniProt Accession

 TPM2_RAT; P58775; P02560; P06395 

Genbank Protein ID

 L00381; L00372; L00373; L00374; L00375; L00376; L00378; L00379; L00380; L00382; L00372; L00373; L00374; L00375; L00376; L00377; L00379; L00380 

Genbank Nucleotide ID

 AAA42288.1; AAA42288.1; AAA42288.1; AAA42288.1; AAA42288.1; AAA42288.1; AAA42288.1; AAA42288.1; AAA42288.1; AAA42289.1; AAA42289.1; AAA42289.1; AAA42289.1; AAA42289.1; AAA42289.1; AAA42289.1; AAA42289.1; AAA42289.1 

Protein Name

 Tropomyosin beta chain 

Protein Synonyms/Alias

 Beta-tropomyosin; Tropomyosin-2 

Gene Name

 Tpm2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
29	AEQAEADKKQAEDRC	acetylation	[1]
30	EQAEADKKQAEDRCK	acetylation	[1]
48	EEQQALQKKLKGTED	acetylation	[1]
49	EQQALQKKLKGTEDE	acetylation	[1]
51	QALQKKLKGTEDEVE	acetylation	[1]
59	GTEDEVEKYSESVKD	acetylation	[1]
65	EKYSESVKDAQEKLE	acetylation	[1]
70	SVKDAQEKLEQAEKK	acetylation	[1]
76	EKLEQAEKKATDAEA	acetylation	[1]
136	VIENRAMKDEEKMEL	acetylation	[1]
140	RAMKDEEKMELQEMQ	acetylation	[1]
149	ELQEMQLKEAKHIAE	acetylation	[1]
152	EMQLKEAKHIAEDSD	acetylation	[1]
168	KYEEVARKLVILEGE	acetylation	[1]
198	GDLEEELKIVTNNLK	acetylation	[1]
205	KIVTNNLKSLEAQAD	acetylation	[1]
213	SLEAQADKYSTKEDK	acetylation	[1]
217	QADKYSTKEDKYEEE	acetylation	[1]
220	KYSTKEDKYEEEIKL	acetylation	[1]
226	DKYEEEIKLLEEKLK	acetylation	[1]
248	FAERSVAKLEKTIDD	acetylation	[1]
251	RSVAKLEKTIDDLED	acetylation	[1]
264	EDEVYAQKMKYKAIS	acetylation	[1]
268	YAQKMKYKAISEELD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity). 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 61 61 Phosphoserine; by PIK3CG (By similarity).
 MOD_RES 252 252 Phosphothreonine (By similarity).
 MOD_RES 283 283 Phosphoserine (By similarity).  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.