UniProt Accession

 SHLB1_HUMAN; Q9Y371; B4E182; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9 

Genbank Protein ID

 AF257318; AF350371; AF263293; AB007960; AF151819; AK001954; AK303710; AL049597; AL049597; BC007455 

Genbank Nucleotide ID

 AAF81225.1; AAK27365.1; AAF73017.1; BAD88797.1; AAD34056.1; BAA91999.1; BAG64694.1; CAC10394.1; CAC10395.1; AAH07455.1 

Protein Name

 Endophilin-B1 

Protein Synonyms/Alias

 Bax-interacting factor 1; Bif-1; SH3 domain-containing GRB2-like protein B1 

Gene Name

 SH3GLB1 

Gene Synonyms/Alias

 KIAA0491; CGI-61 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
9	NIMDFNVKKLAADAG	ubiquitination	[1]
10	IMDFNVKKLAADAGT	ubiquitination	[1]
29	AVQFTEEKLGQAEKT	ubiquitination	[1]
35	EKLGQAEKTELDAHL	ubiquitination	[1]
48	HLENLLSKAECTKIW	ubiquitination	[1]
53	LSKAECTKIWTEKIM	ubiquitination	[1]
58	CTKIWTEKIMKQTEV	ubiquitination	[1]
61	IWTEKIMKQTEVLLQ	ubiquitination	[1]
82	IEEFVYEKLDRKAPS	ubiquitination	[1, 2, 3]
156	NFIEGDYKTIAKERK	ubiquitination	[1]
176	RLDLDAAKTRLKKAK	ubiquitination	[1]
376	ERGNQKGKVPITYLE	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. 

Sequence Annotation

 DOMAIN 27 261 BAR.
 DOMAIN 305 365 SH3.
 REGION 1 30 Membrane-binding amphipathic helix.
 MOD_RES 145 145 Phosphothreonine; by CDK5.  

Keyword

 Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Golgi apparatus; Lipid-binding; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HGNC.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005504; F:fatty acid binding; IEA:Compara.
 GO:0042171; F:lysophosphatidic acid acyltransferase activity; IEA:Compara.
 GO:0051084; P:'de novo' posttranslational protein folding; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IDA:HGNC.
 GO:0006654; P:phosphatidic acid biosynthetic process; IEA:Compara.
 GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; IEA:Compara.
 GO:0032461; P:positive regulation of protein oligomerization; IDA:UniProtKB.
 GO:0051259; P:protein oligomerization; IDA:UniProtKB. 

Interpro

 IPR027267; AH/BAR-dom.
 IPR004148; BAR_dom.
 IPR001452; SH3_domain. 

Pfam

 PF03114; BAR
 PF00018; SH3_1 

SMART

 SM00721; BAR
 SM00326; SH3 

PROSITE

 PS51021; BAR
 PS50002; SH3 

PRINTS