| Tag | Content |
|---|
| CPLM ID | CPLM-009368 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein transport protein Sec61 subunit alpha isoform 1 |
Protein Synonyms/Alias | Sec61 alpha-1 |
Gene Name | SEC61A1 |
Gene Synonyms/Alias | SEC61A |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 148 | FRVDLPIKSARYRGQ | ubiquitination | [1] | | 268 | EVSGSSAKDVAKQLK | ubiquitination | [1] | | 272 | SSAKDVAKQLKEQQM | ubiquitination | [1] | | 275 | KDVAKQLKEQQMVMR | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 476 AA |
Protein Sequence | MIITIGQSIV YVMTGMYGDP SEMGAGICLL ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS 60
LFIATNICET IVWKAFSPTT VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP 120
NLMNLIATIF VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 180
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES FGSVLEDPVH 240
AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRETSMV HELNRYIPTA 300
AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQSEVGS MGALLF 356 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB. GO:0005791; C:rough endoplasmic reticulum; IEA:Compara. GO:0043022; F:ribosome binding; ISS:UniProtKB. GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. GO:0045047; P:protein targeting to ER; ISS:UniProtKB. GO:0034341; P:response to interferon-gamma; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |