| Tag | Content |
|---|
| CPLM ID | CPLM-012086 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Origin recognition complex subunit 2 |
Protein Synonyms/Alias | |
Gene Name | ORC2 |
Gene Synonyms/Alias | ORC2L |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 147 | KGHSASDKVQPKNND | acetylation | [1] |
|
Reference | [1] Integrated proteomic analysis of post-translational modifications by serial enrichment. Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods. 2013 Jul;10(7):634-7. [ PMID: 23749302] |
Functional Description | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
Sequence Annotation | MOD_RES 116 116 Phosphothreonine.
MOD_RES 122 122 Phosphoserine.
MOD_RES 138 138 Phosphoserine.
MOD_RES 226 226 Phosphothreonine.
MOD_RES 280 280 Phosphoserine. |
Keyword | Complete proteome; DNA replication; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 577 AA |
Protein Sequence | MSKPELKEDK MLEVHFVGDD DVLNHILDRE GGAKLKKERA QLLVNPKKII KKPEYDLEED 60
DQEVLKDQNY VEIMGRDVQE SLKNGSATGG GNKVYSFQNR KHSEKMAKLA SELAKTPQKS 120
VSFSLKNDPE ITINVPQSSK GHSASDKVQP KNNDKSEFLS TAPRSLRKRL IVPRSHSDSE 180
SEYSASNSED DEGVAQEHEE DTNAVIFSQK IQAQNRVVSA PVGKETPSKR MKRDKTSDLV 240
EEYFEAHSSS KVLTSDRTLQ KLKRAKLDQQ TLRNLLSKVS PSFSAELKQL NQQYEKLFHK 300
WMLQLHLGFN IVLYGLGSKR DLLERFRTTM LQDSIHVVIN GFFPGISVKS VLNSITEEVL 360
DHMGTFRSIL DQLDWIVNKF KEDSSLELFL LIHNLDSQML RGEKSQQIIG QLSSLHNIYL 420
IASIDHLNAP LMWDHAKQSL FNWLWYETTT YSPYTEETSY ENSLLVKQSG SLPLSSLTHV 480
LRSLTPNARG IFRLLIKYQL DNQDNPSYIG LSFQDFYQQC REAFLVNSDL TLRAQLTEFR 540
DHKLIRTKKG TDGVEYLLIP VDNGTLTDFL EKEEEEA 577 |
Gene Ontology | GO:0000939; C:condensed chromosome inner kinetochore; IEA:Compara. GO:0000792; C:heterochromatin; IEA:Compara. GO:0005664; C:nuclear origin of replication recognition complex; IDA:UniProtKB. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0003688; F:DNA replication origin binding; TAS:ProtInc. GO:0006270; P:DNA replication initiation; TAS:ProtInc. GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |