| Tag | Content |
|---|
| CPLM ID | CPLM-013432 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 29 |
Protein Synonyms/Alias | PTPL1-associated RhoGAP protein 1; Rho-type GTPase-activating protein 29 |
Gene Name | ARHGAP29 |
Gene Synonyms/Alias | PARG1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 113 | EMLTAKVKAVNFTEV | ubiquitination | [1] | | 170 | LPVSRETKSFENVSV | ubiquitination | [1] | | 242 | ESTRNMVKLAEATRT | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. |
Sequence Annotation | DOMAIN 671 886 Rho-GAP.
ZN_FING 612 657 Phorbol-ester/DAG-type.
REGION 1258 1261 Interaction with PTPN13/PTPL1.
MOD_RES 171 171 Phosphoserine (By similarity).
MOD_RES 176 176 Phosphoserine.
MOD_RES 179 179 Phosphoserine.
MOD_RES 190 190 Phosphoserine.
MOD_RES 949 949 Phosphoserine.
MOD_RES 1019 1019 Phosphoserine.
MOD_RES 1146 1146 Phosphoserine. |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; GTPase activation; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1261 AA |
Protein Sequence | MIAHKQKKTK KKRAWASGQL STDITTSEMG LKSLSSNSIF DPDYIKELVN DIRKFSHMLL 60
YLKEAIFSDC FKEVIHIRLE ELLRVLKSIM NKHQNLNSVD LQNAAEMLTA KVKAVNFTEV 120
NEENKNDLFQ EVFSSIETLA FTFGNILTNF LMGDVGNDSL LRLPVSRETK SFENVSVESV 180
DSSSEKGNFS PLELDNVLLK NTDSIELALS YAKTWSKYTK NIVSWVEKKL NLELESTRNM 240
VKLAEATRTN IGIQEFMPLQ SLFTNALLND IESSHLLQQT IAALQANKFV QPLLGRKNEM 300
EKQRKEIKEL WKQEQNKMLE AENALKKAKL LCMQRQDEYE KAKSSMFRAE EEHLSSSGGL 360
AKNLNKQLEK KRRLEEEALQ KVTIFFFFIC KLN 393 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005100; F:Rho GTPase activator activity; TAS:ProtInc. GO:0007266; P:Rho protein signal transduction; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |