CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005356
UniProt Accession
Genbank Protein ID
 M58758 
Genbank Nucleotide ID
Protein Name
 V-type proton ATPase 116 kDa subunit a isoform 1 
Protein Synonyms/Alias
 V-ATPase 116 kDa isoform a1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 
Gene Name
 Atp6v0a1 
Gene Synonyms/Alias
 Atp6n1; Vpp1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
70RKLRFVEKEIRKANIacetylation[1]
74FVEKEIRKANIPIMDubiquitination[2]
119NTNQEALKRNFLELTacetylation[1]
255PETPQERKEMASGVNubiquitination[2]
288RVLQAAAKNIRVWFIubiquitination[2]
366QTPPTYNKTNKFTHGubiquitination[2]
369PTYNKTNKFTHGFQNacetylation[1]
667RHQYLRKKHLGTLNFubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). 
Sequence Annotation
 MOD_RES 250 250 Phosphothreonine (By similarity).
 MOD_RES 364 364 Phosphotyrosine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Hydrogen ion transport; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 838 AA 
Protein Sequence
MGELFRSEEM TLAQLFLQSE AAYCCVSELE ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE 60
MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR 120
NFLELTELKF ILRKTQQFFD EMADPDLLEE SSSLLEPNEM GRGAPLRLGF VAGVINRERI 180
PTFERMLWRV CRGNVFLRQA EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF 240
RASLYPCPET PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM 300
KAIYHTLNLC NIDVTQKCLI AEVWCPVTDL DSIQFALRRG TEHSGSTVPS ILNRMQTNQT 360
PPTYNKTNKF THGFQNIVDA YGIGTYREIN PAPYTVITFP FLFAVMFGDF GHGILMTLFA 420
VWMVLRESRI LSQKNENEMF SMVFSGRYII LLMGLFSIYT GLIYNDCFSK SLNIFGSSWS 480
VRPMFTIGNW TEETLLGSSV LQLNPAIPGV FGGPYPFGID PIWNIATNKL TFLNSFKMKM 540
SVILGIIHML FGVSLSLFNH IYFKKPLNIY FGFIPEIIFM SSLFGYLVIL IFYKWTAYDA 600
HSSRNAPSLL IHFINMFLFS YPESGNAMLY SGQKGIQCFL IVVAMLCVPW MLLFKPLILR 660
HQYLRKKHLG TLNFGGIRVG NGPTEEDAEI IQHDQLSTHS EDAEEPTEDE VFDFGDTMVH 720
QAIHTIEYCL GCISNTASYL RLWALSLAHA QLSEVLWTMV IHIGLHVRSL AGGLGLFFIF 780
AAFATLTVAI LLIMEGLSAF LHALRLHWVE FQNKFYTGTG FKFLPFSFEH IREGKFDE 838 
Gene Ontology
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro. 
Interpro
 IPR002490; V-ATPase_116kDa_su.
 IPR026028; V-type_ATPase_116kDa_su_euka. 
Pfam
 PF01496; V_ATPase_I 
SMART
  
PROSITE
  
PRINTS