UniProt Accession

 MOSC1_HUMAN; Q5VT66; A8K447; B2D078; Q5VVS9; Q5VVT0; Q5VVT1; Q8N9P5; Q96FN8; Q9H6C7 

Genbank Protein ID

 AK026043; AK094105; AK290812; EU563849; AL606726; AL445423; AL445423; AL445423; AL445423; AL606726; CH471100; BC010619 

Genbank Nucleotide ID

 BAB15333.1; BAC04286.1; BAF83501.1; ACB21046.1; CAH71881.1; CAH71881.1; CAH72116.1; CAH72118.1; CAH72119.1; CAH72119.1; EAW93291.1; AAH10619.1 

Protein Name

 MOSC domain-containing protein 1, mitochondrial 

Protein Synonyms/Alias

 Mitochondrial amidoxime reducing component 1; mARC1; Moco sulfurase C-terminal domain-containing protein 1; Molybdenum cofactor sulfurase C-terminal domain-containing protein 1 

Gene Name

 MARC1 

Gene Synonyms/Alias

 MOSC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
67	QLWIYPVKSCKGVPV	ubiquitination	[1]
174	QWITSFLKSQPYRLV	ubiquitination	[2]
265	LIGDVELKRVMACSR	ubiquitination	[1]
327	LENPGTIKVGDPVYL	ubiquitination	[3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. 

Sequence Annotation

 DOMAIN 187 335 MOSC.  

Keyword

 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Molybdenum; Oxidoreductase; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0030151; F:molybdenum ion binding; IDA:UniProtKB.
 GO:0043546; F:molybdopterin cofactor binding; IDA:UniProtKB.
 GO:0008940; F:nitrate reductase activity; IDA:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0051410; P:detoxification of nitrogen compound; NAS:UniProtKB.
 GO:0042126; P:nitrate metabolic process; IDA:UniProtKB. 

Interpro

 IPR005302; MoCF_Sase_C.
 IPR005303; MOSC_N.
 IPR011037; Pyrv_Knase-like_insert_dom. 

Pfam

 PF03473; MOSC
 PF03476; MOSC_N 

SMART

  

PROSITE

 PS51340; MOSC 

PRINTS