| Tag | Content |
|---|
| CPLM ID | CPLM-008982 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Desmocollin-2 |
Protein Synonyms/Alias | Epithelial type 2 desmocollin |
Gene Name | Dsc2 |
Gene Synonyms/Alias | Dsc3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 726 | SRASKQQKILPDDLA | ubiquitination | [1] | | 788 | QETIEMVKGGQQTLD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
Sequence Annotation | DOMAIN 136 243 Cadherin 1.
DOMAIN 244 355 Cadherin 2.
DOMAIN 356 471 Cadherin 3.
DOMAIN 472 579 Cadherin 4.
DOMAIN 580 694 Cadherin 5.
CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
CARBOHYD 392 392 N-linked (GlcNAc...) (Potential).
CARBOHYD 546 546 N-linked (GlcNAc...) (Potential).
CARBOHYD 629 629 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Calcium; Cell adhesion; Cell junction; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 902 AA |
Protein Sequence | MAAVGSMRSG SPAFGLGHLL TLAILALASD ACKEVVLQVP SELPAEKFVG RVNLMDCLKS 60
ADIVHLSDPD FQVLEDGSVY TTSSVVLSSG QRSFTIWLFS TDSQEEREIS VHLEGPVEVL 120
NKRPHTEKVL SRAKRRWAPI PCSMLENSLG PFPLFLQQIQ SDTAQNYTIY YSIRGPGVDK 180
EPLNLFYVER DTGNLYCTGR VDREQYESFE LTAFATTPDG YTPEYPLPLL IKIEDENDNY 240
PIFTQKLYSF TVQENSRIGS IVGEVCATDL DEPDTMHTRL RYSILEQSPS PPMLFTMHPS 300
TGVITTTSAQ LDRELIDKYQ LLIKVQDMDG QYFGLHTTAK CIITIEDVND NLPTFTRTTY 360
VTSVEENTVN VEILRLTVQD KDLVNSPNWR ANYTILKGNE NGNFKIVTDP KTNEGILCVI 420
KPLDYEERQQ VTLQIGVVNE APYTREASSK SPMSTATVTV TVTNQDEGPE CIPPMQTVRI 480
QENVPVGTRN DGYKAYDPET RSSSGIRYRK LSDPRGWVTV NEDSGSITIF RALDREAETV 540
RNGIYNITVL ALDADGRSCT GTLGIILEDV NDNGPFIPKQ TVVICKATMS SAEIVAVDLD 600
DPVNGPPFDF SLESSDSEVQ RMWRLTRIND TAARLSYQND PSFGSYAVPI RVTDRLGLSS 660
VTTLNVLVCD CITESDCTLR SGERTGYADV RLGPWAILAI LLGIALLFCI LFTLVCSVSR 720
ASKQQKILPD DLAQQNLIVS NTEAPGDDKV YSTNGLTTQT MGASGQTAFT TMGTGVKSGG 780
QETIEMVKGG QQTLDSRRGA GYHHHTLDPC RGGHVEVDNY RHTYSEWYNF IQPRLGDKVQ 840
FCHTDDNQKL AQDYVLTYNY EGKGSAAGSV GCCSDLQEED GLEFLDHLEP KFRTLAEVCA 900
KR 902 |
Gene Ontology | GO:0005913; C:cell-cell adherens junction; IDA:MGI. GO:0030057; C:desmosome; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IEA:Compara. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Compara. GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |