CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039522
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Acat3 
Protein Synonyms/Alias
  
Gene Name
 Acat3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
39EMGTTVIKEVLQRAKubiquitination[1]
46KEVLQRAKVAPEEVSubiquitination[1]
124GGMENMSKAPHLTHLubiquitination[1]
170TAENVAKKWQVSREAacetylation[2]
180VSREAQDKVAVLSQNacetylation[2, 3, 4]
180VSREAQDKVAVLSQNubiquitination[1]
194NRAEHAQKAGHFDKEacetylation[5]
194NRAEHAQKAGHFDKEubiquitination[1]
200QKAGHFDKEIVPVLVubiquitination[1]
211PVLVSSRKGLTEVKIubiquitination[1]
217RKGLTEVKIDEFPRHubiquitination[1]
233SNLEAMGKLKPYFLTacetylation[4]
233SNLEAMGKLKPYFLTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 248 AA 
Protein Sequence
MNTRSDPVVI VSAARTAIGS FNGALSTVPV HEMGTTVIKE VLQRAKVAPE EVSEVIFGHV 60
LTAGCGQNPT RQASVGAGIP YSVPAWSCQM ICGSGLKAVC LAAQSIAMGD STIVVAGGME 120
NMSKAPHLTH LRTGVRVGEV PLADSILCDG LTDAFHNYHM GITAENVAKK WQVSREAQDK 180
VAVLSQNRAE HAQKAGHFDK EIVPVLVSSR KGLTEVKIDE FPRHGSNLEA MGKLKPYFLT 240
DGTGTSVT 248 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. 
Interpro
 IPR002155; Thiolase.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr.
 IPR020616; Thiolase_N. 
Pfam
 PF00108; Thiolase_N 
SMART
  
PROSITE
  
PRINTS