| Tag | Content |
|---|
| CPLM ID | CPLM-021095 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongator complex protein 4 |
Protein Synonyms/Alias | PAX6 neighbor gene protein |
Gene Name | Elp4 |
Gene Synonyms/Alias | Paxneb |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 167 | WRYQLQPKMEVGPVS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; Cytoplasm; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 422 AA |
Protein Sequence | MAAADTCGAG TLSSRSVASE AGQGGTSSFQ RKGKASGGPG GGPRLLSIAG TRPSVRNGQL 60
LVSTGLPALD QLLGGGLAVG TLLLIEEDKY NIYSPLLFKY FMAEGIINGH TLLVASAKEN 120
PAKILQELPA PLLDDNSKKE LEDVHSAKTP EPNVNMKIAW RYQLQPKMEV GPVSSSRFGH 180
YYDLSKRIPW ELLQSSKWHG FFLPEHISPD LKGESCFLSC GYMRLLEFIQ KSVYAEGFDG 240
ANPQKKQKNI LRIGIQNLGS PLWGDDICCK ENCDNNHRLT KFLYILRGLL RSSLSACIIT 300
MPAHLVQNKS ITTRVRNLSD TVVGLESFIG SERETNPLYK DYHGLIHIRK IPRLNNLTCD 360
ESDVKDLAFK LKRKLFTIER LHLPPDLSDT VGRSSKQDLA ASTARLGAGC SSMAEGKKHL 420
DF 422 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IEA:Compara. GO:0033588; C:Elongator holoenzyme complex; ISS:UniProtKB. GO:0008023; C:transcription elongation factor complex; ISS:UniProtKB. GO:0004402; F:histone acetyltransferase activity; IEA:Compara. GO:0008607; F:phosphorylase kinase regulator activity; ISS:UniProtKB. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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