CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038464
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Eukaryotic initiation factor 4A-II 
Protein Synonyms/Alias
  
Gene Name
 Eif4a2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
52NVRNEMQKLQAEAPHubiquitination[1]
80NRRYLSPKWIKMFVLubiquitination[1]
197KVDWLTEKMHARDFTacetylation[2, 3]
197KVDWLTEKMHARDFTubiquitination[1]
215LHGDMDQKERDVIMRubiquitination[1]
287NFVTEEDKRILRDIEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 312 AA 
Protein Sequence
MHMVLRSLQL FSKELLSLVL KIQKVILALG DYMGATCHAC IGGTNVRNEM QKLQAEAPHI 60
VVGTPGRVFD MLNRRYLSPK WIKMFVLDEA DEMLSRGFKD QIYEIFQKLN TSIQVVLLSA 120
TMPTDVLEVT KKFMRDPIRI LVKKEELTLE GIKQFYINVE REEWKLDTLC DLYETLTITQ 180
AVIFLNTRRK VDWLTEKMHA RDFTVSALHG DMDQKERDVI MREFRSGSSR VLITTDLLAR 240
GIDVQQVSLV INYDLPTNRE NYIHRIGRGG RFGRKGVAIN FVTEEDKRIL RDIETFYNTT 300
VEEMPMNVAD LI 312 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS