UniProt Accession

 D3YZ57_MOUSE; D3YZ57 

Genbank Protein ID

 AC153422; AC153537 

Genbank Nucleotide ID

  

Protein Name

 Tyrosine-protein kinase Fyn 

Protein Synonyms/Alias

  

Gene Name

 Fyn 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
182	IRESETTKGAYSLSI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 482 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IDA:MGI.
 GO:0015631; F:tubulin binding; IDA:MGI.
 GO:0050798; P:activated T cell proliferation; IMP:MGI.
 GO:0007166; P:cell surface receptor signaling pathway; IDA:MGI.
 GO:0048813; P:dendrite morphogenesis; IMP:MGI.
 GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IMP:MGI.
 GO:0030900; P:forebrain development; IMP:MGI.
 GO:0042552; P:myelination; TAS:MGI.
 GO:0042177; P:negative regulation of protein catabolic process; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.
 GO:0010976; P:positive regulation of neuron projection development; IGI:MGI.
 GO:0046777; P:protein autophosphorylation; IDA:MGI.
 GO:0008360; P:regulation of cell shape; IDA:MGI.
 GO:0045471; P:response to ethanol; IGI:MGI. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR000980; SH2.
 IPR001452; SH3_domain.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 

Pfam

 PF07714; Pkinase_Tyr
 PF00017; SH2
 PF00018; SH3_1 

SMART

 SM00252; SH2
 SM00326; SH3
 SM00219; TyrKc 

PROSITE

 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS50001; SH2
 PS50002; SH3 

PRINTS

 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.
 PR00109; TYRKINASE.