CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001875
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myc proto-oncogene protein 
Protein Synonyms/Alias
 Proto-oncogene c-Myc; Transcription factor p64 
Gene Name
 Myc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
149AAKLVSEKLASYQAAacetylation[1]
323RKDYPAAKRAKLDSGacetylation[1]
417EHKLTSEKDLLRKRRacetylation[1]
Reference
 [1] The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60.
 Patel JH, Du Y, Ard PG, Phillips C, Carella B, Chen CJ, Rakowski C, Chatterjee C, Lieberman PM, Lane WS, Blobel GA, McMahon SB.
 Mol Cell Biol. 2004 Dec;24(24):10826-34. [PMID: 15572685] 
Functional Description
 Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. 
Sequence Annotation
 DOMAIN 354 406 bHLH.
 REGION 413 434 Leucine-zipper.
 MOD_RES 8 8 Phosphothreonine (By similarity).
 MOD_RES 58 58 Phosphothreonine; by GSK3; alternate (By
 MOD_RES 62 62 Phosphoserine; by DYRK2, GSK3 and CDK2
 MOD_RES 71 71 Phosphoserine (By similarity).
 MOD_RES 144 144 N6-acetyllysine; by PCAF (By similarity).
 MOD_RES 149 149 N6-acetyllysine (By similarity).
 MOD_RES 158 158 N6-acetyllysine; by PCAF (By similarity).
 MOD_RES 162 162 Phosphoserine (By similarity).
 MOD_RES 275 275 N6-acetyllysine; by PCAF (By similarity).
 MOD_RES 317 317 N6-acetyllysine; by PCAF (By similarity).
 MOD_RES 323 323 N6-acetyllysine; by PCAF (By similarity).
 MOD_RES 329 329 Phosphoserine; by PIM2; in vitro.
 MOD_RES 371 371 N6-acetyllysine; by PCAF (By similarity).
 CARBOHYD 58 58 O-linked (GlcNAc); alternate (By  
Keyword
 Acetylation; Activator; Complete proteome; DNA-binding; Glycoprotein; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 439 AA 
Protein Sequence
MPLNVNFTNR NYDLDYDSVQ PYFICDEEEN FYHQQQQSEL QPPAPSEDIW KKFELLPTPP 60
LSPSRRSGLC SPSYVAVATS FSPREDDDGG GGNFSTADQL EMMTELLGGD MVNQSFICDP 120
DDETFIKNII IQDCMWSGFS AAAKLVSEKL ASYQAARKDS TSLSPARGHS VCSTSSLYLQ 180
DLTAAASECI DPSVVFPYPL NDSSSPKSCT SSDSTAFSPS SDSLLSSESS PRASPEPLVL 240
HEETPPTTSS DSEEEQEDEE EIDVVSVEKR QTPAKRSESG SSPSRGHSKP PHSPLVLKRC 300
HVSTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCSSPRSSDT EENDKRRTHN 360
VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSIQADE HKLTSEKDLL 420
RKRREQLKHK LEQLRNSGA 439 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0016604; C:nuclear body; IDA:MGI.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0005819; C:spindle; IDA:MGI.
 GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IDA:MGI.
 GO:0070888; F:E-box binding; ISS:UniProtKB.
 GO:0032403; F:protein complex binding; ISS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.
 GO:0001783; P:B cell apoptotic process; IMP:MGI.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
 GO:0060070; P:canonical Wnt receptor signaling pathway; ISS:UniProtKB.
 GO:0006879; P:cellular iron ion homeostasis; ISS:UniProtKB.
 GO:0035690; P:cellular response to drug; IDA:UniProtKB.
 GO:0006338; P:chromatin remodeling; ISS:UniProtKB.
 GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IMP:MGI.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:MGI.
 GO:0000165; P:MAPK cascade; ISS:UniProtKB.
 GO:0042474; P:middle ear morphogenesis; IMP:MGI.
 GO:0051782; P:negative regulation of cell division; ISS:UniProtKB.
 GO:0045656; P:negative regulation of monocyte differentiation; ISS:UniProtKB.
 GO:0032091; P:negative regulation of protein binding; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0043473; P:pigmentation; IMP:MGI.
 GO:2001235; P:positive regulation of apoptotic signaling pathway; IDA:MGI.
 GO:0002904; P:positive regulation of B cell apoptotic process; IGI:MGI.
 GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
 GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:UniProtKB.
 GO:0048146; P:positive regulation of fibroblast proliferation; ISS:UniProtKB.
 GO:0090096; P:positive regulation of metanephric cap mesenchymal cell proliferation; IMP:UniProtKB.
 GO:2001022; P:positive regulation of response to DNA damage stimulus; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0016485; P:protein processing; IMP:MGI.
 GO:0032204; P:regulation of telomere maintenance; ISS:UniProtKB.
 GO:0043279; P:response to alkaloid; IMP:MGI.
 GO:0010332; P:response to gamma radiation; ISS:UniProtKB.
 GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
 GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011598; bHLH_dom.
 IPR003327; Myc-LZ.
 IPR002418; Tscrpt_reg_Myc.
 IPR012682; Tscrpt_reg_Myc_N. 
Pfam
 PF00010; HLH
 PF02344; Myc-LZ
 PF01056; Myc_N 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS
 PR00044; LEUZIPPRMYC.