CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034086
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein PML 
Protein Synonyms/Alias
  
Gene Name
 Pml 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
372QEEPQNQKVQLLTRGubiquitination[1]
454TQPVAMVKTVPGAHPubiquitination[1]
545PESTVPEKKILLPNNacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 641 AA 
Protein Sequence
METEPVSVQK VPAPPGSPCR QQDSALTPTP TMPPPEEPSE DYEHSQSPAE QAIQEEFQFL 60
RCPSCQAQAK CPKLLPCLHT LCSGCLEAPG LQCPICKAPG QADANGEALD NVFFESLQRR 120
LAVFRQIVDA QAACTRCKGL ADFWCFECEQ LICSKCFEAH QWYLKHEARP LADLRDNSVS 180
SFLDSTRKSN IFCSNTNHRN PALTDIYCRG CAKPLCCTCA LLDRNHSHLH CDIGEEIQQW 240
HEELGTMTQT LEEQGRTFDS AHAQMCSAIG QLDHARADIE KQIRARVRQV VDYVQAQERE 300
LLEAVNDRYQ RDYQEIAGQL SCLEAVLQRI RTSGALVKRM KLYASDQEVL DMHSFLRKAL 360
CSLRQEEPQN QKVQLLTRGF EEFKLCLQDF ISCITQRINA AVASPEAASN QPEAASTHPV 420
TTSTPEDLEQ PKEVQSVQAQ ALELSKTQPV AMVKTVPGAH PVPVYAFSMQ GPTYREEASQ 480
TVGSMKRKCS HEDCSRKIIK MESTEENEDR LATSSPEQSW PSTFKATSPP HLDGTSNPES 540
TVPEKKILLP NNNHVTSDTG ETEERVVVIS SSEDSDTENL SSHELDDSSS ESSSLQLEGP 600
NSLKALDESL AEPHLEDRTL VFFDLKIDNE SGFPKTYLTS F 641 
Gene Ontology
 GO:0016363; C:nuclear matrix; IDA:MGI.
 GO:0016605; C:PML body; IDA:MGI.
 GO:0046332; F:SMAD binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI.
 GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.
 GO:0045165; P:cell fate commitment; IMP:MGI.
 GO:0071353; P:cellular response to interleukin-4; IDA:MGI.
 GO:0007182; P:common-partner SMAD protein phosphorylation; IMP:MGI.
 GO:0006917; P:induction of apoptosis; IMP:MGI.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:MGI.
 GO:0051457; P:maintenance of protein location in nucleus; ISO:MGI.
 GO:0030099; P:myeloid cell differentiation; IMP:MGI.
 GO:0016525; P:negative regulation of angiogenesis; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0030578; P:PML body organization; IDA:MGI.
 GO:0045343; P:regulation of MHC class I biosynthetic process; IDA:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0010332; P:response to gamma radiation; IMP:MGI.
 GO:0001666; P:response to hypoxia; IMP:MGI.
 GO:0009411; P:response to UV; IMP:MGI.
 GO:0048384; P:retinoic acid receptor signaling pathway; IMP:MGI.
 GO:0007184; P:SMAD protein import into nucleus; IMP:MGI.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:MGI. 
Interpro
 IPR021978; DUF3583.
 IPR000315; Znf_B-box.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF12126; DUF3583
 PF00643; zf-B_box 
SMART
 SM00336; BBOX
 SM00184; RING 
PROSITE
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS