CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013686
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein of 78 kDa 
Protein Synonyms/Alias
 Cep78 
Gene Name
 CEP78 
Gene Synonyms/Alias
 C9orf81 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
317LQNGRSAKSEYQWITubiquitination[1, 2]
329WITSPSVKEPSKTAKubiquitination[2]
375GRKHSLGKEYYAPAPubiquitination[2]
579NPPKEEKKALEDEKPubiquitination[3]
585KKALEDEKPEPKQNAubiquitination[3]
619GTLMKFQKITGDARIubiquitination[3]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 689 AA 
Protein Sequence
MIDSVKLRRD SAADFFSHYE YLCALQNSVP LPAVRACLRE GVLDFNADRL RGVDWAPLLS 60
TLKINKDLPL VSIKSFFQPW LGDTGSDMNK FCRSRVPAIR YKDVTFQLCK ALKGCLSISS 120
VLKNLELNGL ILRERDLTIL AKGLNKSASL VHLSLANCPI GDGGLEIICQ GIKSSITLKT 180
VNFTGCNLTW QGADHMAKIL KYQTMRRHEE TWAESLRYRR PDLDCMAGLR RITLNCNTLI 240
GDLGACAFAD SLSEDLWLRA LDLQQCGLTN EGAKALLEAL ETNTTLVVLD IRKNPLIDHS 300
MMKAVIKKVL QNGRSAKSEY QWITSPSVKE PSKTAKQKRR TIILGSGHKG KATIRIVGLA 360
TKKPVSSGRK HSLGKEYYAP APLPPGVSGF LPWRTAERAK RHRGFPLIKT RDICNQLQQP 420
GFPVTVTVES PSSSEVEEVD DSSESVHEVP EKTSIEQEAL QEKLEECLKQ LKEERVIRLK 480
VDKRVSELEH ENAQLRNINF SLSEALHAQS LTNMILDDEG VLGSIENSFQ KFHAFLDLLK 540
DAGLGQLATM AGIDQSDFQL LGHPQMTSTV SNPPKEEKKA LEDEKPEPKQ NALGQMQNIQ 600
VSICMQSAYN EGTLMKFQKI TGDARIPLPL DSFPVPVSTP EGLGTSSNNL GVPATEQRQE 660
SFEGFIARMC SPSPDATSGT GSQRKEEELS RNSRSSSEKK TKTGEYTKKH SDKQHPGKDL 720
HS 722 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome. 
Interpro
 IPR026212; Cep78. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR02062; CENTROSOME78.