CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041720
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Breast cancer type 1 susceptibility protein homolog 
Protein Synonyms/Alias
 RCG34321, isoform CRA_a 
Gene Name
 Brca1 
Gene Synonyms/Alias
 rCG_34321 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1073QSAPVSDKYLEIKQEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1817 AA 
Protein Sequence
MDLSAVRIQE VQNVLHAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 60
CPLCKNEITK RSLQGSARFS QLVEELLKII DAFELDTGMQ CANGFSFSKK KNSSSELLNE 120
DASIIQSVGY RNRVKKLRQI ESGSATLKDS LSVQLSNLGI VRSMKKNRQT QPQNKSVYIA 180
LESDSSEERV NAPDGCSVRD QELFQIAPGG AGDEGKLNSA KKAACDFSEG IRNIEHHQCS 240
DKDLNPTENH ATERHPEKCP RISVANVHVE PCGTDARASS LQRGTRSLLF TEDRLDAEKA 300
EFCDRSKQSG AAVSQQSRWA DSKETCNGRP VPRTEGKADP NVDSLCGRKQ WNHPKSLCPE 360
NSGATTDVPW ITLNSSIQKV NEWFSRTGEM LTSDNASDRR PASNAEAAVV LEVSNEVDGC 420
FSSSKKIDLV APDSDNAVMC TSGRDFSKPV ENIINDKIFG KTYQRKGSRP HLNHVTEIIG 480
TFTTEPQIIQ EQPFTNKLKR KRSTCLHPED FIKKADLTVV QRISENLNQG TDQMEPNDQA 540
MSITSNGQEN RATGNDLQRG RNAHPIESLR KEPAFTAKAK SISNSISDLE VELNVHSSKA 600
PKKNRLRRKS TRCVLPLEPI SRNPSPPTCA ELQIESCGSS EETKKNNSNQ TPAGHIREPQ 660
LIEDTEPAAD AKKNEPNEHI RKRSASDAFP EEKLMNKAGL LTSCSSPRKP QGPVNPSPER 720
KGIEQLEMCQ MPDNNKELGD LVLGGEPSGK PTEPSEESTS VSLVPDTDYD TQNSVSILEA 780
NTVRYARTGS VQCMTQFVAS ENPKELVHGS NNAGSGSECF KHPLRHELNH NQETIEMEDS 840
ELDTQYLQNT FQVSKRQSFA LFSKLRSPQK DCTLVGARSV PSREPSPKVT SRGEQKERQG 900
QEESEISHVQ AVTVTVGLPV PCQEGKPGAV TMCADVSRLC PSSHYRSCEN GLNTTDKSGI 960
SQNSHFRQSV SPLRSSIKTD NRKTLTEGRF EKHTERGMGN ETAVQSTIHT ISQNNRGDAC 1020
QEASSGSVIE VHSTGENVQG QLDRNRGPTV NTVSLLDSTQ PGVSKQSAPV SDKYLEIKQE 1080
SKAVSADFSP CLFSDHLEKP MRSDKIFQVC SETPDDLLDD VEIQENASFG EGGITEKSAI 1140
FNGSVLRRES SRIPSPVTHA SKSRSLHRGS RKLEFSEESD STEDEDLPCF QHLLSRVSST 1200
PELTRCSSVV TQRVPEKAKG TQAPRKSSIS DCNNEVILVE ASQEYQFSED AKCSGSMFSS 1260
QHSAALGSPA NALSQDPDFN PPSKQRRHQA ENEEAFLSDK ELISDHEDMA ACLEEASDQE 1320
EDSIIPDSVA SGYESEANLS EDCSQSDILT TQQRATMKDN LIKLQQEMAQ LEAVLEQHGS 1380
QPSGHPPCLP ADPCALEDLP DPEQNRSGTA ILTSKNINEN PVSQNPKRAC DDKSQPQPPD 1440
GLPSGDKESG MRRPSPFKSP LTSRRCSARG HSRSLQNRNS TSQEELLQPV ELEKSCEPHN 1500
LTGRSCLPRQ DLEGTPYLES GISLFSSRDP DSESPKVPAL VCTAPASTSA LKISQGQVAG 1560
SCRSPAAGGA DTAVVEIVSK IKPEVTSSKE RAERDISMVV SGLTPKEVMI VQKFAEKYRL 1620
ALTDVITEET THVIIKTDAE FVCERTLKYF LGIAGGKWIV SYSWVIKSIQ ERKLLSVHEF 1680
EVKGDVVTGS NHQGPRRSRE SQEKLFEGLQ IYCCEPFTNM PKDELERMLQ LCGASVVKEL 1740
PLLTRDTGAH PIVLVQPSAW TEDNDCPDIG QLCKGRLVMW DWVLDSISVY RCRDLDAYLV 1800
QNITCGRDGS EPQDSND 1817 
Gene Ontology
 GO:0000794; C:condensed nuclear chromosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0003684; F:damaged DNA binding; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007098; P:centrosome cycle; IEA:Compara.
 GO:0043009; P:chordate embryonic development; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:Compara.
 GO:0009048; P:dosage compensation by inactivation of X chromosome; IEA:Compara.
 GO:0035067; P:negative regulation of histone acetylation; IEA:Compara.
 GO:0051572; P:negative regulation of histone H3-K4 methylation; IEA:Compara.
 GO:0051573; P:negative regulation of histone H3-K9 methylation; IEA:Compara.
 GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:Compara.
 GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Compara.
 GO:0051574; P:positive regulation of histone H3-K9 methylation; IEA:Compara.
 GO:2000620; P:positive regulation of histone H4-K16 acetylation; IEA:Compara.
 GO:0070512; P:positive regulation of histone H4-K20 methylation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0044030; P:regulation of DNA methylation; IEA:Compara.
 GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Compara. 
Interpro
 IPR011364; BRCA1.
 IPR025994; BRCA1_serine_dom.
 IPR001357; BRCT_dom.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00533; BRCT
 PF12820; BRCT_assoc 
SMART
 SM00292; BRCT
 SM00184; RING 
PROSITE
 PS50172; BRCT
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS
 PR00493; BRSTCANCERI.