CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038299
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Heat shock protein HSP 90-beta 
Protein Synonyms/Alias
  
Gene Name
 Hsp90ab1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
66EDKENYKKFYEAFSKacetylation[1]
66EDKENYKKFYEAFSKsuccinylation[1]
66EDKENYKKFYEAFSKubiquitination[2]
73KFYEAFSKNLKLGIHacetylation[1, 3, 4]
73KFYEAFSKNLKLGIHubiquitination[2]
76EAFSKNLKLGIHEDSacetylation[3]
76EAFSKNLKLGIHEDSubiquitination[2]
115SEYVSRMKETQKSIYacetylation[3]
119SRMKETQKSIYYITGacetylation[1, 3, 4]
119SRMKETQKSIYYITGsuccinylation[1]
119SRMKETQKSIYYITGubiquitination[2]
129YYITGESKEQVANSAacetylation[3, 4]
129YYITGESKEQVANSAubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 161 AA 
Protein Sequence
MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDC LELFSELAED 60
KENYKKFYEA FSKNLKLGIH EDSTNRRRLS ELLRYHTSQS GDEMTSLSEY VSRMKETQKS 120
IYYITGESKE QVANSAFVER VRKRGFEVVY MTEPIDEYCV Q 161 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0071353; P:cellular response to interleukin-4; IDA:MGI.
 GO:0001890; P:placenta development; IMP:MGI.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0006950; P:response to stress; IEA:InterPro. 
Interpro
 IPR003594; HATPase_ATP-bd.
 IPR019805; Heat_shock_protein_90_CS.
 IPR001404; Hsp90.
 IPR020575; Hsp90_N.
 IPR020568; Ribosomal_S5_D2-typ_fold. 
Pfam
 PF00183; HSP90 
SMART
  
PROSITE
 PS00298; HSP90 
PRINTS
 PR00775; HEATSHOCK90.