CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015841
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interleukin enhancer-binding factor 2 
Protein Synonyms/Alias
 Liver regeneration-related protein LRRG031 
Gene Name
 Ilf2 
Gene Synonyms/Alias
 Ab1-143 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
166EMAFPRVKPAPDETSubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity). 
Sequence Annotation
 DOMAIN 199 411 DZF.
 MOD_RES 461 461 Phosphothreonine (By similarity).  
Keyword
 Activator; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 463 AA 
Protein Sequence
MVSTHLTSTT LPDCYRSLIV NSELGSSALM DLNSPSFLYP LLHTPADKGT LCTYQAALGK 60
VYASLEVIGV GDDKLQAVHG LNGGKPHRDI LGSRITRPTG IKPLCLPRHI LAYDWLAQSL 120
LGIVIGSISL AYNELLMMEK LKGFRPFVPH IPFDFYLCEM AFPRVKPAPD ETSFSEALLK 180
RNQDLAPNSA EQQIEEVRQV GSYKKGTMTT GHNVADLVVI LKILPTFLTM LTNETGFEIS 240
SSDATVKILI TTVPPNLRKL DPELHLDIKV LQSALAAIRH ARWFEENASQ STVKVLIRLL 300
KDLRIRFPGF EPLTPWILDL LGHYAVMNNP TRQPLALNVA YRRCLQILAA GLFLPGSVGI 360
TDPCESGNFR VHTVMTLEQQ DMVCYTAQTL VRILSHGGFR KILGQEGDAS YLASEISTWD 420
GVIVTPSEKA YEKPPEKKEG EEEEENTEEP PQGEEEESME TQE 463 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0003725; F:double-stranded RNA binding; ISS:UniProtKB.
 GO:0016740; F:transferase activity; IEA:InterPro.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; ISS:UniProtKB. 
Interpro
 IPR006116; 2-5-oligoadenylate_synth_N.
 IPR006561; DZF. 
Pfam
 PF07528; DZF 
SMART
 SM00572; DZF 
PROSITE
  
PRINTS