CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014025
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylate kinase domain-containing protein 1 
Protein Synonyms/Alias
 Adenylate kinase domain-containing protein 2 
Gene Name
 AKD1 
Gene Synonyms/Alias
 AKD2; C6orf199; C6orf224 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55RYITQAWKCIRVEALubiquitination[1]
148PDVIINIKCPDYDLCubiquitination[1]
322FRTLASYKLIAPRYRubiquitination[1]
344RTCPVNLKDGNIYSGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 NP_BIND 40 45 ATP 1 (By similarity).
 NP_BIND 87 89 AMP 1 (By similarity).
 NP_BIND 116 119 AMP 1 (By similarity).
 NP_BIND 1001 1006 ATP 2 (By similarity).
 NP_BIND 1050 1052 AMP 2 (By similarity).
 NP_BIND 1079 1082 AMP 2 (By similarity).
 NP_BIND 1421 1426 ATP 3 (By similarity).
 NP_BIND 1470 1472 AMP 3 (By similarity).
 NP_BIND 1499 1502 AMP 3 (By similarity).
 REGION 31 285 Adenylate kinase 1.
 REGION 60 89 NMPbind 1 (By similarity).
 REGION 160 205 LID 1 (By similarity).
 REGION 992 1203 Adenylate kinase 2.
 REGION 1021 1052 NMPbind 2 (By similarity).
 REGION 1124 1144 LID 2 (By similarity).
 REGION 1412 1601 Adenylate kinase 3.
 REGION 1441 1472 NMPbind 3 (By similarity).
 REGION 1536 1550 LID 3 (By similarity).
 BINDING 229 229 AMP 1 (By similarity).
 BINDING 1447 1447 AMP 3 (By similarity).
 BINDING 1506 1506 AMP 3 (By similarity).
 BINDING 1543 1543 AMP 3 (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1911 AA 
Protein Sequence
MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI TQAWKCIRVE 60
ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE KLNSPEVCHF GYIITEIPSL 120
SQDAMTTLQQ IELIKNLNLK PDVIINIKCP DYDLCQRISG QRQHNNTGYI YSRDQWDPEV 180
IENHRKKKKE AQKDGKGEEE EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI 240
VKLYKETILQ TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG 300
AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS GLPDYSVSFL 360
GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ YSGKTTLCNM LAENYKGKVV 420
DYAQLVQPRF DKARETLVEN TIAEATAAAI KVVKEKLLRE LQARKQAETA LREFQRQYEK 480
MEFGVFPMEA THSSIDEEGY IQGSQRDRGS SLVDTEEAKT KSENVLHDQA AKVDKDDGKE 540
TGETFTFKRH SQDASQDVKL YSDTAPTEDL IEEVTADHPE VVTMIEETIK MSQDINFEQP 600
YEKHAEILQE VLGEVMEENK DRFPGAPKYG GWIVDNCPIV KELWMALIKK GIIPDLVIYL 660
SDTENNGKCL FNRIYLQKKS EIDSKILERL LEELQKKKKE EEEARKATEE ELRLEEENRR 720
LLELMKVKAK EAEETDNEDE EEIEGDELEV HEEPEASHDT RGSWLPEEFE ASEVPETEPE 780
AVSEPIEETT VETEIPKGSK EGLEIEKLSE TVVLPEFPED SYPDVPEMEP FKEKIGSFII 840
LWKQLEATIS EAYIKILNLE IADRTPQELL QKVVETMEKP FQYTAWELTG EDYEEETEDY 900
QTEAEVDEEL EEEEEEEGED KMKERKRHLG DTKHFCPVVL KENFILQPGN TEEAAKYREK 960
IYYFSSAEAK EKFLEHPEDY VAHEEPLKAP PLRICLVGPQ GSGKTMCGRQ LAEKLNIFHI 1020
QFEEVLQEKL LLKTEKKVGP EFEEDSENEQ AAKQELEELA IQANVKVEEE NTKKQLPEVQ 1080
LTEEEEVIKS SLMENEPLPP EILEVILSEW WLKEPIRSTG FILDGFPRYP EEAQFLGDRG 1140
FFPDAAVFIQ VDDQDIFDRL LPAQIEKWKL KQKKKLERKK LIKDMKAKIR VDTIAKRRAE 1200
LILERDKKRR ENVVRDDEEI SEEELEEDND DIENILEDEF PKDEEEMSGE EDEEQETDAI 1260
ERLRGELGEK FEADTHNLQI IQDELERYLI PIISINGARR NHIVQYTLNM KLKPLVENRA 1320
SIFEKCHPIP APLAQKMLTF TYKYISSFGY WDPVKLSEGE TIKPVENAEN PIYPVIHRQY 1380
IYFLSSKETK EKFMKNPIKY IRQPKPKPTV PIRIIIVGPP KSGKTTVAKK ITSEYGLKHL 1440
SIGGALRYVL NNHPETELAL MLNWHLHKGM TAPDELAIQA LELSLMESVC NTAGVVIDGY 1500
PVTKHQMNLL EARSIIPMVI FELSVPSKEI FKRLLLEKEN EQRLPYPLHN SAQIVAVNNV 1560
KYRKNIGEIR QYYQEQHQNW YVIDGFHSKW WVWNEVIKNV QMVNKYMQTY LERIKAGKAA 1620
CIDKLCITPQ ELLSRLGEFE QFCPVSLAES QELFDCSATD SLEFAAEFRG HYYKMSSQEK 1680
LNKFLENPEL YVPPLAPHPL PSADMIPKRL TLSELKSRFP KCAELQGYCP VTYKDGNQRY 1740
EALVPGSINY ALEYHNRIYI CENKEKLQKF LRSPLKYWEQ KLPHKLPPLR EPILLTSLPL 1800
PGYLEQGIAT SLIKAMNAAG CLKPKFPFLS IRRSALLYIA LHLKAFNPKG SEYTRKKYKK 1860
KMEQFMESCE LITYLGAKMT RKYKEPQFRA IDFDHKLKTF LSLRNIDPIN G 1911 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0019205; F:nucleobase-containing compound kinase activity; IEA:InterPro.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR000850; Adenylate_kin.
 IPR027417; P-loop_NTPase.
 IPR007029; YHS_dom. 
Pfam
 PF00406; ADK
 PF04945; YHS 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS