CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008361
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras-related protein Rab-27A 
Protein Synonyms/Alias
 Rab-27; GTP-binding protein Ram 
Gene Name
 RAB27A 
Gene Synonyms/Alias
 RAB27 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
33LYQYTDGKFNSKFITubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. 
Sequence Annotation
 NP_BIND 16 24 GTP (By similarity).
 NP_BIND 74 78 GTP (By similarity).
 NP_BIND 133 136 GTP (By similarity).
 NP_BIND 163 165 GTP (By similarity).
 MOTIF 38 46 Effector region (By similarity).
 MOD_RES 211 211 Phosphoserine (By similarity).
 MOD_RES 221 221 Cysteine methyl ester (By similarity).
 LIPID 219 219 S-geranylgeranyl cysteine (By
 LIPID 221 221 S-geranylgeranyl cysteine (By
 DISULFID 123 188 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Endosome; Exocytosis; GTP-binding; Lipoprotein; Lysosome; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Polymorphism; Prenylation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 221 AA 
Protein Sequence
MSDGDYDYLI KFLALGDSGV GKTSVLYQYT DGKFNSKFIT TVGIDFREKR VVYRASGPDG 60
ATGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWISQLQMH 120
AYCENPDIVL CGNKSDLEDQ RVVKEEEAIA LAEKYGIPYF ETSAANGTNI SQAIEMLLDL 180
IMKRMERCVD KSWIPEGVVR SNGHASTDQL SEEKEKGACG C 221 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0030425; C:dendrite; IDA:UniProtKB.
 GO:0070382; C:exocytic vesicle; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0042470; C:melanosome; IDA:UniProtKB.
 GO:0032585; C:multivesicular body membrane; IDA:UniProtKB.
 GO:0001750; C:photoreceptor outer segment; IEA:Compara.
 GO:0030667; C:secretory granule membrane; IEA:Compara.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0007596; P:blood coagulation; IEA:Compara.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0043316; P:cytotoxic T cell degranulation; IEA:Compara.
 GO:0006887; P:exocytosis; IDA:UniProtKB.
 GO:0030318; P:melanocyte differentiation; IEA:Compara.
 GO:0032402; P:melanosome transport; IEA:Compara.
 GO:0071985; P:multivesicular body sorting pathway; IMP:UniProtKB.
 GO:0043320; P:natural killer cell degranulation; IEA:Compara.
 GO:0045921; P:positive regulation of exocytosis; IMP:UniProtKB.
 GO:0006605; P:protein targeting; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 
Pfam
 PF00071; Ras 
SMART
 SM00175; RAB 
PROSITE
 PS51419; RAB 
PRINTS
 PR00449; RASTRNSFRMNG.