UniProt Accession

 IIGP1_MOUSE; Q9QZ85; Q9Z1M3 

Genbank Protein ID

 AJ007971; AF194871; AK153060; CT010300; BC004649 

Genbank Nucleotide ID

 CAA07798.1; AAF07195.1; BAE31686.1; CAJ18508.1; AAH04649.1 

Protein Name

 Interferon-inducible GTPase 1 

Protein Synonyms/Alias

  

Gene Name

 Iigp1 

Gene Synonyms/Alias

 Irga6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
25	SSFTGYFKKFNTGRK	ubiquitination	[1]
32	KKFNTGRKIISQEIL	ubiquitination	[1]
48	LIELRMRKGNIQLTN	ubiquitination	[1]
101	NEEEGAAKTGVVEVT	ubiquitination	[1]
176	KAISMMKKEFYFVRT	ubiquitination	[1]
196	ITNEADGKPQTFDKE	ubiquitination	[1]
202	GKPQTFDKEKVLQDI	acetylation	[2]
202	GKPQTFDKEKVLQDI	ubiquitination	[1]
204	PQTFDKEKVLQDIRL	ubiquitination	[1]
273	ITDSVIEKKRQFLKQ	ubiquitination	[1]
352	IKSPAVFKPTDEETI	ubiquitination	[1]
385	LPKNSFLKEIFYLKY	ubiquitination	[1]
403	DMVTEDAKTLLKEIC	ubiquitination	[1]
407	EDAKTLLKEICLRN*	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction. 

Sequence Annotation

 NP_BIND 77 84 GTP.
 NP_BIND 102 106 GTP.
 NP_BIND 184 186 GTP.
 NP_BIND 231 233 GTP.
 MOD_RES 84 84 Phosphoserine.
 LIPID 2 2 N-myristoyl glycine (Probable).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Endoplasmic reticulum; Golgi apparatus; GTP-binding; Hydrolase; Immunity; Innate immunity; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 413 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0020005; C:symbiont-containing vacuole membrane; IDA:UniProtKB.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0042802; F:identical protein binding; IDA:MGI.
 GO:0035458; P:cellular response to interferon-beta; IDA:MGI.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:MGI.
 GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
 GO:0042832; P:defense response to protozoan; IDA:UniProtKB.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0010506; P:regulation of autophagy; IMP:UniProtKB. 

Interpro

 IPR007743; Interferon-induced_GTPase.
 IPR027417; P-loop_NTPase. 

Pfam

 PF05049; IIGP 

SMART

  

PROSITE

  

PRINTS