UniProt Accession

 CD166_HUMAN; Q13740; B2RNS3; B4DTU0; O60892; Q1HGM8; Q1HGM9 

Genbank Protein ID

 L38608; DQ486139; DQ486140; AK300362; AK316113; AC023602; AC078806; AC133476; BC137096; BC137097; Y10183 

Genbank Nucleotide ID

 AAB59499.1; ABF48405.1; ABF48406.1; BAG62102.1; BAH14484.1; AAI37097.1; AAI37098.1; CAA71256.1 

Protein Name

 CD166 antigen 

Protein Synonyms/Alias

 Activated leukocyte cell adhesion molecule; CD166 

Gene Name

 ALCAM 

Gene Synonyms/Alias

 MEMD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
550	TASKHVNKDLGNMEE	ubiquitination	[1]
559	LGNMEENKKLEENNH	ubiquitination	[1]
567	KLEENNHKTEA****	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. 

Sequence Annotation

 DOMAIN 28 120 Ig-like V-type 1.
 DOMAIN 125 234 Ig-like V-type 2.
 DOMAIN 245 328 Ig-like C2-type 1.
 DOMAIN 333 409 Ig-like C2-type 2.
 DOMAIN 416 501 Ig-like C2-type 3.
 CARBOHYD 91 91 N-linked (GlcNAc...).
 CARBOHYD 95 95 N-linked (GlcNAc...).
 CARBOHYD 167 167 N-linked (GlcNAc...).
 CARBOHYD 265 265 N-linked (GlcNAc...).
 CARBOHYD 306 306 N-linked (GlcNAc...) (Potential).
 CARBOHYD 361 361 N-linked (GlcNAc...) (Potential).
 CARBOHYD 457 457 N-linked (GlcNAc...).
 CARBOHYD 466 466 N-linked (GlcNAc...); atypical.
 CARBOHYD 480 480 N-linked (GlcNAc...).
 CARBOHYD 499 499 N-linked (GlcNAc...).
 DISULFID 43 113 Potential.
 DISULFID 157 220 Potential.
 DISULFID 270 313 Potential.
 DISULFID 354 392 Potential.
 DISULFID 435 485 Potential.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 583 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005102; F:receptor binding; TAS:ProtInc.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0008045; P:motor neuron axon guidance; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 

Pfam

 PF08205; C2-set_2
 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS