| Tag | Content |
|---|
| CPLM ID | CPLM-010678 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA-directed RNA polymerase II subunit RPB3 |
Protein Synonyms/Alias | RNA polymerase II subunit 3; RNA polymerase II subunit B3; DNA-directed RNA polymerase II 33 kDa polypeptide; RPB33; DNA-directed RNA polymerase II subunit C; RPB31 |
Gene Name | Polr2c |
Gene Synonyms/Alias | Rpo2-3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 81 | TSDDIVDKLQYSRDC | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). |
Sequence Annotation | MOD_RES 124 124 Phosphoserine (By similarity). |
Keyword | Complete proteome; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Reference proteome; Transcription. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 275 AA |
Protein Sequence | MPYANQPTVR ITELTEENVK FIIENTDLAV ANSIRRVFIA EVPIIAIDWV QIDGNSSVLH 60
DEFIAHRLGL IPLTSDDIVD KLQYSRDCTC EEFCPECSVE FTLDVRCNED QTRHVTSRDL 120
ISNSPRVIPV TSRNRDNDPN DYVEQDDILI VKLRKGQELR LRAYVKKRSG KEHAKWNPTA 180
GVAFEYDPDN GLRHTVYPKP EEGPKSEYSE LDEDESQAPY DPNGKPERFY YNVESCGSLR 240
PETIGLSALS GLKKKLSDLQ TQLSHEIQSD VLTIN 275 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:MGI. GO:0005665; C:DNA-directed RNA polymerase II, core complex; ISS:UniProtKB. GO:0003677; F:DNA binding; IEA:InterPro. GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW. GO:0006366; P:transcription from RNA polymerase II promoter; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |