UniProt Accession

 MOSC1_MOUSE; Q9CW42; Q8R2L6 

Genbank Protein ID

 AK004989; BC028441 

Genbank Nucleotide ID

 BAB23724.1; AAH28441.1 

Protein Name

 MOSC domain-containing protein 1, mitochondrial 

Protein Synonyms/Alias

 Mitochondrial amidoxime reducing component 1; mARC1; Moco sulfurase C-terminal domain-containing protein 1; Molybdenum cofactor sulfurase C-terminal domain-containing protein 1 

Gene Name

 Marc1 

Gene Synonyms/Alias

 Mosc1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
70	QLWIYPIKSCKGLSV	ubiquitination	[1]
73	IYPIKSCKGLSVSEA	ubiquitination	[1]
199	PRSSRQMKAVFRTKD	ubiquitination	[1]
205	MKAVFRTKDQVAYSD	ubiquitination	[1]
291	DTGISDRKEPLETLK	acetylation	[2]
291	DTGISDRKEPLETLK	ubiquitination	[1]
298	KEPLETLKSYRLCDP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively (By similarity). 

Sequence Annotation

 DOMAIN 191 338 MOSC.  

Keyword

 Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Molybdenum; Oxidoreductase; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 340 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0030151; F:molybdenum ion binding; IEA:InterPro.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. 

Interpro

 IPR005302; MoCF_Sase_C.
 IPR005303; MOSC_N.
 IPR011037; Pyrv_Knase-like_insert_dom. 

Pfam

 PF03473; MOSC
 PF03476; MOSC_N 

SMART

  

PROSITE

 PS51340; MOSC 

PRINTS