CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011189
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TPR repeat-containing protein YMR018W 
Protein Synonyms/Alias
  
Gene Name
 YMR018W; YM9711.06 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
449GDYVKASKMLIEVILacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Unknown, but in contrast to the closely related PEX5, it is not involved in the binding of type-1 peroxisome-targeting sequences (PTS1) nor in peroxisome biogenesis or fatty acid oxidation. 
Sequence Annotation
 REPEAT 174 207 TPR 1.
 REPEAT 218 252 TPR 2.
 REPEAT 254 286 TPR 3.
 REPEAT 288 320 TPR 4.
 REPEAT 326 359 TPR 5.
 REPEAT 360 393 TPR 6.
 REPEAT 394 427 TPR 7.
 REPEAT 429 461 TPR 8.  
Keyword
 Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 514 AA 
Protein Sequence
MNEVTCSITG DNPIHKINNG LGLKWNNLGK FSDFQTNDSA ARDARTIDYI FTNCQTGSSI 60
GKIDFRAALP ADKSQHSGVS EKEFSRLENQ WSKEFSCFPK NKNADVTKPS RNKHEKRSAN 120
LHNRYFAQYY STAYQQNRIY PCRISYNEHS SVSNGWEFQF KSIENQLLNE LKIENNVEEK 180
TVGYEYVAEY EETIDFMHML SSVPQTYQFL KSNIYITERD PYKIGCVLMD NGSNLNEVVM 240
AFEAAISQDP SHINAWLKLG IVNFENESES NGELALRNCL NLDPNNTIAL ENLAIHHINQ 300
QNESESLKLF HKWILSKFSK VFQPSAGENK DSINKIPKKA HLAHILESLL NMGIEKKDQY 360
DIYSVLSILY YSDQKIKQSQ KCLEFLLLEK PNNGTIWNRY GAILANTKSY HSAINAYNKC 420
KQLRPNFTRV RYNLAIAYMN KGDYVKASKM LIEVILLRSK GYEHNKAKMQ NKFMQNLKNA 480
LIASKNFDSL DLINGSHNTE SLISTLKAIY NKMD 514 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005778; C:peroxisomal membrane; IBA:RefGenome.
 GO:0005052; F:peroxisome matrix targeting signal-1 binding; IBA:RefGenome.
 GO:0016558; P:protein import into peroxisome matrix; IBA:RefGenome. 
Interpro
 IPR024111; PTS1R_family.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
  
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS