CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006178
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock protein homolog SSE2 
Protein Synonyms/Alias
  
Gene Name
 SSE2 
Gene Synonyms/Alias
 HSP; YBR169C; YBR1221 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
584YIYTLRAKLDDEYSDacetylation[1]
661RANQETSKMNDIAEKubiquitination[2]
668KMNDIAEKLAEQRRAubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Has a calcium-dependent calmodulin-binding activity. 
Sequence Annotation
  
Keyword
 ATP-binding; Calmodulin-binding; Complete proteome; Nucleotide-binding; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 693 AA 
Protein Sequence
MSTPFGLDLG NNNSVLAVAR NRGIDVVVNE VSNRSTPSLV GFGPRNRYLG ESGKTKQTSN 60
VKNTVENLKR IIGLKFKDPE FDIENKFFTS KLVQLKNGKV GVEVEFGGKT HVFSATQLTA 120
MFIDKVKHTV QEETKSSITD VCLAVPVWYS EEQRYNIADA ARIAGLNPVR IVNDVTAAAV 180
SYGVFKNDLP GPEEKPRIIG LVDIGHSTYT CSIMAFRKGE MKVLGTAYDK HFGGRDFDRA 240
ITEHFADQFK DKYKIDIRKN PKAYNRILIA AEKLKKVLSA NTTAPFSVES VMDDIDVSSQ 300
LSREELEELV EPLLKRVTYP ITNALAQAKL TVNDIDFVEI IGGTTRIPVL KKSISDVFGK 360
PLSSTLNQDE AVAKGAAFIC AIHSPTLRVR PFKFEDIDPY SVSYTWDKQV DDEDRLEVFP 420
ANSSYPSTKL ITLHRTGDFS MKAVYTHPSK LPKGTSTTIA KWSFTGVKVP KDQDFIPVKV 480
KLRCDPSGLH IIENAYTTED ITVQEPVPLP EDAPEDAEPQ FKEVTKTIKK DVLGMTAKTF 540
ALNPVELNDL IEKENELRNQ DKLVAETEDR KNALEEYIYT LRAKLDDEYS DFASDAEKEK 600
LKNMLATTEN WLYGDGDDST KAKYIAKYEE LASLGNIIRG RYLAKEEEKR QALRANQETS 660
KMNDIAEKLA EQRRARAASD DSDDNNDENM DLD 693 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0000774; F:adenyl-nucleotide exchange factor activity; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042026; P:protein refolding; IGI:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.