CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001983
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Troponin C, skeletal muscle 
Protein Synonyms/Alias
  
Gene Name
 TNNC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38GGGDISVKELGTVMRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. 
Sequence Annotation
 DOMAIN 15 50 EF-hand 1.
 DOMAIN 51 86 EF-hand 2.
 DOMAIN 91 126 EF-hand 3.
 DOMAIN 127 160 EF-hand 4.
 MOD_RES 2 2 N-acetylthreonine.  
Keyword
 Acetylation; Calcium; Complete proteome; Direct protein sequencing; Metal-binding; Muscle protein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 160 AA 
Protein Sequence
MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT PTKEELDAII 60
EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF RIFDRNADGY IDPEELAEIF 120
RASGEHVTDE EIESLMKDGD KNNDGRIDFD EFLKMMEGVQ 160 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005861; C:troponin complex; IDA:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0030049; P:muscle filament sliding; TAS:Reactome.
 GO:0006937; P:regulation of muscle contraction; TAS:ProtInc.
 GO:0003009; P:skeletal muscle contraction; IDA:UniProtKB. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF13499; EF_hand_5 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS