CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014449
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Major vault protein 
Protein Synonyms/Alias
 MVP 
Gene Name
 Mvp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
444RGQKGTAKPLQPSAPacetylation[1]
745EGSVLQAKLKAQALAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity). 
Sequence Annotation
 REPEAT 2 56 MVP 1.
 REPEAT 57 111 MVP 2.
 REPEAT 112 164 MVP 3.
 REPEAT 165 217 MVP 4.
 REPEAT 218 272 MVP 5.
 REPEAT 273 323 MVP 6.
 REPEAT 324 379 MVP 7.
 REPEAT 380 457 MVP 8.
 REPEAT 458 520 MVP 9.
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 3D-structure; Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 861 AA 
Protein Sequence
MATEEAIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPVRM VTVPPRHYCI 60
VANPVSRDTQ SSVLFDITGQ VRLRHADQEI RLAQDPFPLY PGEVLEKDIT PLQVVLPNTA 120
LHLKALLDFE DKNGDKVMAG DEWLFEGPGT YIPQKEVEVV EIIQATVIKQ NQALRLRARK 180
ECFDREGKGR VTGEEWLVRS VGAYLPAVFE EVLDLVDAVI LTEKTALHLR ALQNFRDLRG 240
VLHRTGEEWL VTVQDTEAHV PDVYEEVLGV VPITTLGPRH YCVILDPMGP DGKNQLGQKR 300
VVKGEKSFFL QPGERLERGI QDVYVLSEQQ GLLLKALQPL EEGESEEKVS HQAGDCWLIR 360
GPLEYVPSAK VEVVEERQAI PLDQNEGIYV QDVKTGKVRA VIGSTYMLTQ DEVLWEKELP 420
SGVEELLNLG HDPLADRGQK GTAKPLQPSA PRNKTRVVSY RVPHNAAVQV YDYRAKRARV 480
VFGPELVTLD PEEQFTVLSL SAGRPKRPHA RRALCLLLGP DFFTDVITIE TADHARLQLQ 540
LAYNWHFELK NRNDPAEAAK LFSVPDFVGD ACKAIASRVR GAVASVTFDD FHKNSARIIR 600
MAVFGFEMSE DTGPDGTLLP KARDQAVFPQ NGLVVSSVDV QSVEPVDQRT RDALQRSVQL 660
AIEITTNSQE AAAKHEAQRL EQEARGRLER QKILDQSEAE KARKELLELE AMSMAVESTG 720
NAKAEAESRA EAARIEGEGS VLQAKLKAQA LAIETEAELE RVKKVREMEL IYARAQLELE 780
VSKAQQLANV EAKKFKEMTE ALGPGTIRDL AVAGPEMQVK LLQSLGLKST LITDGSSPIN 840
LFSTAFGLLG LGSDGQPPAQ K 861 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW. 
Interpro
 IPR021870; MVP_shoulder.
 IPR002499; Vault_N. 
Pfam
 PF11978; MVP_shoulder
 PF01505; Vault 
SMART
  
PROSITE
 PS51224; MVP 
PRINTS