CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012351
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol 1,4,5-trisphosphate receptor type 1 
Protein Synonyms/Alias
 IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor 
Gene Name
 ITPR1 
Gene Synonyms/Alias
 INSP3R1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
230FMKWSDNKDDILKGGubiquitination[1]
2232ERDEQGSKINDFFLRubiquitination[1]
2251FNEMNWQKKLRAQPVubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). 
Sequence Annotation
 DOMAIN 112 166 MIR 1.
 DOMAIN 173 223 MIR 2.
 DOMAIN 231 287 MIR 3.
 DOMAIN 294 373 MIR 4.
 DOMAIN 379 435 MIR 5.
 REGION 265 269 Inositol 1,4,5-trisphosphate binding (By
 REGION 508 511 Inositol 1,4,5-trisphosphate binding (By
 REGION 567 569 Inositol 1,4,5-trisphosphate binding (By
 REGION 2472 2537 Interaction with ERP44 (By similarity).
 MOD_RES 482 482 Phosphotyrosine (Potential).
 MOD_RES 1598 1598 Phosphoserine.
 MOD_RES 1764 1764 Phosphoserine.
 MOD_RES 2664 2664 Phosphotyrosine (Potential).
 CARBOHYD 2512 2512 N-linked (GlcNAc...).
 CROSSLNK 917 917 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 972 972 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 1581 1581 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 1780 1780 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 1893 1893 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 1894 1894 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 1895 1895 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 1910 1910 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 1933 1933 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 2127 2127 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 2266 2266 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Apoptosis; Calcium; Calcium channel; Calcium transport; Complete proteome; Disease mutation; Endoplasmic reticulum; Glycoprotein; Ion channel; Ion transport; Isopeptide bond; Ligand-gated ion channel; Membrane; Neurodegeneration; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Spinocerebellar ataxia; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2758 AA 
Protein Sequence
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 60
CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 120
IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 180
KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 240
RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 300
SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 360
RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPVKE DKEAFAIVPV 420
SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 480
EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 540
CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 600
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 660
EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE LAQDAKEGQK EDRDVLSYYR 720
YQLNLFARMC LDRQYLAINE ISGQLDVDLI LRCMSDENLP YDLRASFCRL MLHMHVDRDP 780
QEQVTPVKYA RLWSEIPSEI AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF 840
SDKEKNKLTF EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 900
NKGNNDVEKL KSSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV KQAEPEKEDI 960
MVMDTKLKII EILQFILNVR LDYRISCLLC IFKREFDESN SQTSETSSGN SSQEGPSNVP 1020
GALDFEHIEE QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR 1080
HFSQRQEVLQ AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDETMDG 1140
ASGENEHKKT EEGNNKPQKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL 1200
RNMGAHAVVL ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL HKHINLFLNP 1260
GILEAVTMQH IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK 1320
CQDMVMAELV NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLMYHI HLVELLAVCT 1380
EGKNVYTEIK CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH 1440
MWKLFENFLV DICRACNNTS DRKHADSILE KYVTEIVMSI VTTFFSSPFS DQSTTLQTRQ 1500
PVFVQLLQGV FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD SQVNNLFLKS 1560
HSIVQKTAMN WRLSARNAAR RDSVLAASRD YRNIIERLQD IVSALEDRLR PLVQAELSVL 1620
VDVLHRPELL FPENTDARRK CESGGFICKL IKHTKQLLEE NEEKLCIKVL QTLREMMTKD 1680
RGYGEKLISI DELDNAELPP APDSENATEE LEPSPPLRQL EDHKRGEALR QVLVNRYYGN 1740
VRPSGRRESL TSFGNGPLSA GGPGKPGGGG GGSGSSSMSR GEMSLAEVQC HLDKEGASNL 1800
VIDLIMNASS DRVFHESILL AIALLEGGNT TIQHSFFCRL TEDKKSEKFF KVFYDRMKVA 1860
QQEIKATVTV NTSDLGNKKK DDEVDRDAPS RKKAKEPTTQ ITEEVRDQLL EASAATRKAF 1920
TTFRREADPD DHYQPGEGTQ ATADKAKDDL EMSAVITIMQ PILRFLQLLC ENHNRDLQNF 1980
LRCQNNKTNY NLVCETLQFL DCICGSTTGG LGLLGLYINE KNVALINQTL ESLTEYCQGP 2040
CHENQNCIAT HESNGIDIIT ALILNDINPL GKKRMDLVLE LKNNASKLLL AIMESRHDSE 2100
NAERILYNMR PKELVEVIKK AYMQGEVEFE DGENGEDGAA SPRNVGHNIY ILAHQLARHN 2160
KELQSMLKPG GQVDGDEALE FYAKHTAQIE IVRLDRTMEQ IVFPVPSICE FLTKESKLRI 2220
YYTTERDEQG SKINDFFLRS EDLFNEMNWQ KKLRAQPVLY WCARNMSFWS SISFNLAVLM 2280
NLLVAFFYPF KGVRGGTLEP HWSGLLWTAM LISLAIVIAL PKPHGIRALI ASTILRLIFS 2340
VGLQPTLFLL GAFNVCNKII FLMSFVGNCG TFTRGYRAMV LDVEFLYHLL YLVICAMGLF 2400
VHEFFYSLLL FDLVYREETL LNVIKSVTRN GRSIILTAVL ALILVYLFSI VGYLFFKDDF 2460
ILEVDRLPNE TAVPETGESL ASEFLFSDVC RVESGENCSS PAPREELVPA EETEQDKEHT 2520
CETLLMCIVT VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV IIIVLNLIFG 2580
VIIDTFADLR SEKQKKEEIL KTTCFICGLE RDKFDNKTVT FEEHIKEEHN MWHYLCFIVL 2640
VKVKDSTEYT GPESYVAEMI KERNLDWFPR MRAMSLVSSD SEGEQNELRN LQEKLESTMK 2700
LVTNLSGQLS ELKDQMTEQR KQKQRIGLLG HPPHMNVNPQ QPA 2743 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031088; C:platelet dense granule membrane; IDA:BHF-UCL.
 GO:0031095; C:platelet dense tubular network membrane; TAS:Reactome.
 GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; ISS:UniProtKB.
 GO:0005218; F:intracellular ligand-gated calcium channel activity; ISS:UniProtKB.
 GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
 GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; ISS:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
 GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.
 GO:0001666; P:response to hypoxia; IDA:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR000699; Ca-rel_channel.
 IPR014821; Ins145_P3_rcpt.
 IPR000493; InsP3_rcpt-bd.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR015925; Ryanodine_recept-rel. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF01365; RYDR_ITPR 
SMART
 SM00472; MIR 
PROSITE
 PS50919; MIR 
PRINTS
 PR00779; INSP3RECEPTR.