UniProt Accession

 VTI1A_MOUSE; O89116; Q545P9 

Genbank Protein ID

 AF035823; AF035209; AK004751; AK028646; BC019386 

Genbank Nucleotide ID

 AAC32049.1; AAC23482.1; BAB23532.1; BAC26046.1; AAH19386.1 

Protein Name

 Vesicle transport through interaction with t-SNAREs homolog 1A 

Protein Synonyms/Alias

 Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2 

Gene Name

 Vti1a 

Gene Synonyms/Alias

 Vti1; Vti1l2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	QMVANVEKQLEEARE	ubiquitination	[1]
176	DADANLGKSSRILTG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be concerned with increased secretion of cytokines associated with cellular senescence. 

Sequence Annotation

  

Keyword

 3D-structure; Coiled coil; Complete proteome; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0042147; P:retrograde transport, endosome to Golgi; ISS:UniProtKB. 

Interpro

 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom.
 IPR007705; Vesicle_trsprt_v-SNARE_N. 

Pfam

 PF05008; V-SNARE 

SMART

 SM00397; t_SNARE 

PROSITE

  

PRINTS