UniProt Accession

 RMI2_HUMAN; Q96E14; B3KVZ6; Q49AE2; Q8TBL0 

Genbank Protein ID

 AK123764; AC009121; CH471112; BC013040; BC022427; BC031016; BC039361 

Genbank Nucleotide ID

 BAG53958.1; EAW85155.1; AAH13040.2; AAH22427.1; AAH31016.1; AAH39361.1 

Protein Name

 RecQ-mediated genome instability protein 2 

Protein Synonyms/Alias

 hRMI2; BLM-associated protein of 18 kDa; BLAP18 

Gene Name

 RMI2 

Gene Synonyms/Alias

 C16orf75 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	LPRSPPLKVLAEQLR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress- induced nuclear foci and mitotic phosphorylation of BLM. 

Sequence Annotation

 DNA_BIND 44 114 OB.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 7 7 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; DNA replication; DNA-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 

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