| Tag | Content |
|---|
| CPLM ID | CPLM-019071 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PHD finger protein 21A |
Protein Synonyms/Alias | BHC80a; BRAF35-HDAC complex protein BHC80 |
Gene Name | PHF21A |
Gene Synonyms/Alias | BHC80; KIAA1696; BM-006 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 25 | QKLVAQMKQDPQNAD | ubiquitination | [1] | | 185 | VNLQTSSKVTGPGAE | ubiquitination | [1] | | 326 | PQTVQLSKPSLEKQT | ubiquitination | [1] | | 335 | SLEKQTVKSHTETDE | ubiquitination | [1] | | 578 | LKWSSDLKQEREQLE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. |
Sequence Annotation | DNA_BIND 425 437 A.T hook.
ZN_FING 488 535 PHD-type.
REGION 486 680 Required for transcriptional repression.
MOD_RES 444 444 Phosphothreonine.
MOD_RES 447 447 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 680 AA |
Protein Sequence | MELQTLQEAL KVEIQVHQKL VAQMKQDPQN ADLKKQLHEL QAKITALSEK QKRVVEQLRK 60
NLIVKQEQPD KFQIQPLPQS ENKLQTAQQQ PLQQLQQQQQ YHHHHAQQSA AASPNLTASQ 120
KTVTTASMIT TKTLPLVLKA ATATMPASVV GQRPTIAMVT AINSQKAVLS TDVQNTPVNL 180
QTSSKVTGPG AEAVQIVAKN TVTLQVQATP PQPIKVPQFI PPPRLTPRPN FLPQVRPKPV 240
AQNNIPIAPA PPPMLAAPQL IQRPVMLTKF TPTTLPTSQN SIHPVRVVNG QTATIAKTFP 300
MAQLTSIVIA TPGTRLAGPQ TVQLSKPSLE KQTVKSHTET DEKQTESRTI TPPAAPKPKR 360
EENPQKLAFM VSLGLVTHDH LEEIQSKRQE RKRRTTANPV YSGAVFEPER KKSAVTYLNS 420
TMHPGTRKRG RPPKYNAVLG FGALTPTSPQ SSHPDSPENE KTETTFTFPA PVQPVSLPSP 480
TSTDGDIHED FCSVCRKSGQ LLMCDTCSRV YHLDCLDPPL KTIPKGMWIC PRCQDQMLKK 540
EEAIPWPGTL AIVHSYIAYK AAKEEEKQKL LKWSSDLKQE REQLEQKVKQ LSNSISKCME 600
MKNTILARQK EMHSSLEKVK QLIRLIHGID LSKPVDSEAT VGAISNGPDC TPPANAATST 660
PAPSPSSQSC TANCNQGEET K 681 |
Gene Ontology | GO:0000118; C:histone deacetylase complex; IDA:MGI. GO:0003682; F:chromatin binding; IEA:Compara. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007596; P:blood coagulation; TAS:Reactome. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0001967; P:suckling behavior; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |