CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022035
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Something about silencing protein 10 
Protein Synonyms/Alias
 Charged amino acid-rich leucine zipper 1; CRL1; Disrupter of silencing SAS10; UTP3 homolog 
Gene Name
 UTP3 
Gene Synonyms/Alias
 CRLZ1; SAS10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
191AWVEAFAKPVPQVDEubiquitination[1]
221EKLKMLRKESPELLEubiquitination[1, 2]
260QGIIPPGKGSQYLRTubiquitination[3]
310TYRNLINKLSVVDQKubiquitination[2, 3, 4]
317KLSVVDQKLSSEIRHubiquitination[1, 3, 4, 5, 6, 7]
329IRHLLTLKDDAVKKEubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). 
Sequence Annotation
 MOD_RES 37 37 Phosphoserine.
 MOD_RES 150 150 Phosphoserine.
 MOD_RES 362 362 Phosphothreonine.
 MOD_RES 365 365 Phosphoserine.
 MOD_RES 368 368 Phosphoserine.  
Keyword
 Chromatin regulator; Complete proteome; Developmental protein; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MVGRSRRRGA AKWAAVRAKA GPTLTDENGD DLGLPPSPGD TSYYQDQVDD FHEARSRAAL 60
AKGWNEVQSG DEEDGEEEEE EVLALDMDDE DDEDGGNAGE EEEEENADDD GGSSVQSEAE 120
ASVDPSLSWG QRKKLYYDTD YGSKSRGRQS QQEAEEEERE EEEEAQIIQR RLAQALQEDD 180
FGVAWVEAFA KPVPQVDEAE TRVVKDLAKV SVKEKLKMLR KESPELLELI EDLKVKLTEV 240
KDELEPLLEL VEQGIIPPGK GSQYLRTKYN LYLNYCSNIS FYLILKARRV PAHGHPVIER 300
LVTYRNLINK LSVVDQKLSS EIRHLLTLKD DAVKKELIPK AKSTKPKPKS VSKTSAAACA 360
VTDLSDDSDF DEKAKLKYYK EIEDRQKLKR KKEENSTEEQ ALEDQNAKRA ITYQIAKNRG 420
LTPRRKKIDR NPRVKHREKF RRAKIRRRGQ VREVRKEEQR YSGELSGIRA GVKKSIKLK 479 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:LIFEdb.
 GO:0007420; P:brain development; ISS:UniProtKB.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. 
Interpro
 IPR007146; Sas10/Utp3/C1D.
 IPR018972; Sas10_C_dom. 
Pfam
 PF04000; Sas10_Utp3
 PF09368; Sas10_Utp3_C 
SMART
  
PROSITE
  
PRINTS