UniProt Accession

 A2AGS2_MOUSE; A2AGS2 

Genbank Protein ID

 AL603826; AL691461 

Genbank Nucleotide ID

  

Protein Name

 Dual-specificity mitogen-activated protein kinase kinase 6 

Protein Synonyms/Alias

  

Gene Name

 Map2k6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
232	INPELNQKGYSVKSD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 293 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0000187; P:activation of MAPK activity; IDA:MGI.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IMP:MGI.
 GO:0000165; P:MAPK cascade; IPI:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IDA:MGI.
 GO:0042493; P:response to drug; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS