CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004200
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cholesterol side-chain cleavage enzyme, mitochondrial 
Protein Synonyms/Alias
 CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc) 
Gene Name
 Cyp11a1 
Gene Synonyms/Alias
 Cyp11a; Cyp11a-1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
191IKQQNSGKFSGDISDacetylation[1]
366QAQGDMAKMVQLVPLacetylation[1]
379PLLKASIKETLRLHPacetylation[1]
431SFFPNPNKFDPTRWLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. 
Sequence Annotation
 METAL 459 459 Iron (heme axial ligand) (By similarity).  
Keyword
 Cholesterol metabolism; Complete proteome; Heme; Iron; Lipid metabolism; Membrane; Metal-binding; Mitochondrion; Monooxygenase; Oxidoreductase; Reference proteome; Steroid metabolism; Steroidogenesis; Sterol metabolism; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MLAKGLCLRS VLVKSCQPFL SPVWQGPGLA TGNGAGISST NSPRSFNEIP SPGDNGWINL 60
YHFLRENGTH RIHYHHMQNF QKYGPIYREK LGNMESVYIL DPKDAATLFS CEGPNPERYL 120
VPPWVAYHQY YQRPIGVLFK SSDAWRKDRI VLNQEVMAPD SIKNFVPLLE GVAQDFIKVL 180
HRRIKQQNSG KFSGDISDDL FRFAFESITS VVFGERLGML EEIVDPESQR FIDAVYQMFH 240
TSVPMLNMPP DLFRLFRTKT WKDHAAAWDV IFSKADEYTQ NFYWDLRQKR DFSKYPGVLY 300
SLLGGNKLPF KNIQANITEM LAGGVDTTSM TLQWNLYEMA HNLKVQEMLR AEVLAARRQA 360
QGDMAKMVQL VPLLKASIKE TLRLHPISVT LQRYIVNDLV LRNYKIPAKT LVQVASYAMG 420
RESSFFPNPN KFDPTRWLEK SQNTTHFRYL GFGWGVRQCL GRRIAELEMT IFLINVLENF 480
RIEVQSIRDV GTKFNLILMP EKPIFFNFQP LKQDLGSTMP RKGDTV 526 
Gene Ontology
 GO:0030061; C:mitochondrial crista; IDA:RGD.
 GO:0043204; C:perikaryon; IDA:RGD.
 GO:0015485; F:cholesterol binding; IMP:RGD.
 GO:0008386; F:cholesterol monooxygenase (side-chain-cleaving) activity; IMP:RGD.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; ISS:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0018879; P:biphenyl metabolic process; IEP:RGD.
 GO:0071236; P:cellular response to antibiotic; IEP:RGD.
 GO:0071276; P:cellular response to cadmium ion; IEP:RGD.
 GO:0071320; P:cellular response to cAMP; IEP:RGD.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEP:RGD.
 GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEP:RGD.
 GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
 GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
 GO:0071375; P:cellular response to peptide hormone stimulus; IEP:RGD.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
 GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
 GO:0021549; P:cerebellum development; IEP:RGD.
 GO:0008203; P:cholesterol metabolic process; ISS:UniProtKB.
 GO:0018894; P:dibenzo-p-dioxin metabolic process; IEP:RGD.
 GO:0006703; P:estrogen biosynthetic process; IEP:RGD.
 GO:0050756; P:fractalkine metabolic process; IEP:RGD.
 GO:0060014; P:granulosa cell differentiation; IEP:RGD.
 GO:0021766; P:hippocampus development; IEP:RGD.
 GO:0033327; P:Leydig cell differentiation; IEP:RGD.
 GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD.
 GO:0007617; P:mating behavior; IMP:RGD.
 GO:0018958; P:phenol-containing compound metabolic process; IEP:RGD.
 GO:0018963; P:phthalate metabolic process; IEP:RGD.
 GO:0006701; P:progesterone biosynthetic process; IEP:RGD.
 GO:0001101; P:response to acid; IEP:RGD.
 GO:0043279; P:response to alkaloid; IEP:RGD.
 GO:0051412; P:response to corticosterone stimulus; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0060992; P:response to fungicide; IEP:RGD.
 GO:0010332; P:response to gamma radiation; IEP:RGD.
 GO:0033595; P:response to genistein; IEP:RGD.
 GO:0042542; P:response to hydrogen peroxide; IMP:RGD.
 GO:0017085; P:response to insecticide; IEP:RGD.
 GO:0033591; P:response to L-ascorbic acid; IEP:RGD.
 GO:0009651; P:response to salt stress; IEP:RGD.
 GO:0033197; P:response to vitamin E; IEP:RGD.
 GO:0014037; P:Schwann cell differentiation; IEP:RGD.
 GO:0061370; P:testosterone biosynthetic process; IEP:RGD. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.