CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042141
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 LOC100734820 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
1521NESTDVTKGDSKNAKacetylation[1]
1525DVTKGDSKNAKKKNNacetylation[1]
1528KGDSKNAKKKNNKKTacetylation[1]
1529GDSKNAKKKNNKKTSacetylation[1]
1530DSKNAKKKNNKKTSKacetylation[1]
1533NAKKKNNKKTSKNKSacetylation[1]
1534AKKKNNKKTSKNKSSacetylation[1]
1537KNNKKTSKNKSSLSRacetylation[1]
1539NKKTSKNKSSLSRGNacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2362 AA 
Protein Sequence
DFGSLFDLEH DLPDELINST ELGLTNGGDI NQLQTNLGMA QDAASKHKQL SELLRSGSSP 60
NLNMGVGGPG QVMASQAQQN SPGLGLINSM VKSPMAQAGL TSPNMGMGTS GPNQGPTQST 120
TGMMNSPVNQ PAMGMNTGMN AGMNPGMLAA GSGQGLMPGQ VMNGSIGAGR GRPNMQYSNP 180
GMANAGNLMT EPLQQGSPQM GGQTGMRGPQ PLKMGIMNNP NPYGSPYTQN SGQQIGASGL 240
GLQIQAKTVL PNNLSPFPMD KKAVPGGGMP SMVQQPGLVT PVTQGMGSGA HTADPEKRKL 300
IQQQLVLLLH AHKCQRREQA NGEVRQCNLP HCRTMKNVLN HMTHCQSGKS CQVAHCASSR 360
QIISHWKNCT RHDCPVCLPL KNAGDKRNQQ SILTGAPVGL GNPSSLGVGQ QSTPSLSTVS 420
QIDPSSIERA YAALGLPYSG NQMPPQSQVQ AKNQQNQQSG QSPQGIRPMN SMSASPMGVN 480
GGVGVQAPNL LSDSMLHSAI NSQNPMMSEN ASVASLGPMP TAAQPSSTGI RKQWHEDITQ 540
DLRNHLVHKL VQAIFPTPDP AALKDRRMEN LVAYARKVEG DMYESANNRA EYYHLLAEKI 600
YKIQKELEEK RRTRLQKQNM LPNAAGMVPV SMNPGPNMGQ PQSAMASNGP LPDPGNILLI 660
FTGLNQFGPM SMPQPPIGPR QTSPLQHHGQ LAQPGALNLI AISCSLQPMG YGPRLQQPSS 720
QGQFLSQTQF PAQGMNVTNM PLPPSTGQVS VSQAQMSSSS CPVNSPVMPP GSQGSHIHCP 780
PLPQQALHQN SPSPVPSRTP TPHHTPPSIG AQQPPPTAIP APVPTPPAIP SGPQPQGLHP 840
PSRQTPTPPT AQLPPQVQPS LPTAPSADQV QQQPRSQQST AASIPTPTAP LLPPQPTTPL 900
SQPAVSIEGQ VSNPPSTSST EVNSQTIPEK QPSQEVKMDA KMEMDQPEPT DAQPEDIQEV 960
RHKLLQRIQF LKINNTNVEE CKVEPTETEE RNMELKPEIK EEEDQPSTSA TQSSPAPGQS 1020
KKKIFKPEEL RQALMPTLEA LYRQDPESLP FRQPVDPQLL GIPDYFDIVK SPMDLSTIKR 1080
KLDTGQYQEP WQYVDDIWLM FNNAWLYNRK TSRVYKYCSK LSEVFEQEID PVMQSLGYCC 1140
GRKLEFSPQT LCCYGKQLCT IPRDATYYSY QNRYHFCEKC FNEIQGESVS LGDDPSQPQT 1200
TINKEQFSKR KNDTLDPELF VECTECGRKM HQICVLHHEI IWPAGFVCDG CLKKTARTRK 1260
ENKFSAKRLP STRLGTFLEN RVNDFLRRQN HPESGEVTVR VVHASDKTVE VKPGMKARFV 1320
DSGEMAESFP YRTKALFAFE EIDGVDLCFF GMHVQEYGSD CPPPNQRRVY ISYLDSVHFF 1380
RPKCLRTTVY HEILIGYLEY VKKLGYTTGH IWACPPSEGD DYIFHCHPPD QKIPKPKRLQ 1440
EWYKKMLDKA VSERIVHDYK PCNQCFKQAT EDRLTSAKEL PYFEGDFWPN VLEESIKELE 1500
QEEEERKREE NTSNESTDVT KGDSKNAKKK NNKKTSKNKS SLSRGNKKKP GMPNVSNDLS 1560
QKLYATMEKH KEVFFVIRLI AGPAANSLPP IVDPDPLIPC DLMDGRDAFL TLARDKHLEF 1620
SSLRRAQWST MCMLVELHTQ SQDRFVYTCN ECKHHVETRW HCTVCEDYDL CITCYNTKNH 1680
DHKMEKLGLG LDDESNNQQA AATQSPGDSR RLSIQRCIQS LVHACQCRNA NCSLPSCQKM 1740
KRVVQHTKGC KRKTNGGCPI CKQLIALCCY HAKHCQENKC PVPFCLNIKQ KLRQQQLQHR 1800
LQQAQMLRRR MASMQRTGVV GQQQGLPSPT PATPTTPTGQ QPTTPQTPMP PYLPRTQTAG 1860
PVSQGKAAGQ VTPPTPPQTA QPPLPGPPPA AVEMAMQIQR AAETQRQMAH VQIFQRPIQH 1920
QMPQMTPMTP IGMNPPPMTR GPSGHLEPGM GPTAMQQQLP WAQGGLPQPQ PLQSSMPRPA 1980
MMSVAQHGQP LNMAPQPGLG QVGVSPLKPG TVSQQALQNL LRTLRSPSSP LQQQQVLSIL 2040
HANPQLLAAF IKQRAAKYAN SNPQPLTGQP GMAQGQPGLQ PPAMPGQQGV HSNAAMQNMN 2100
PMQAGVQRTG LAQQQPQQQL QPPMGGMSPQ AQPMNVNHSS MSSQFRDMLR QQQMMRQQQQ 2160
GAGPGIGPGM ANHNQFQQPQ GVGYPMQQGN IGQMGQLPQA LGAEAGASLQ AYQQRLLQQQ 2220
MGSPAQPNPM SPQQHMLPNQ AQSPHLQGQQ IPNSLSNQVR SPQPVPSPRP QSQPPHSSPS 2280
PRMQPQPSPH HVSPQTSSPH PGLVAAQAAN PMEQGHFASP DQNPMLSQLA SHPEYTRHTL 2340
ETPCSILGNK TFCTENNFLE SF 2362 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000123; C:histone acetyltransferase complex; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0031490; F:chromatin DNA binding; IEA:Compara.
 GO:0001047; F:core promoter binding; IEA:Compara.
 GO:0004402; F:histone acetyltransferase activity; IEA:Compara.
 GO:0004468; F:lysine N-acetyltransferase activity; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0043967; P:histone H4 acetylation; IEA:Compara.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Compara.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0018076; P:N-terminal peptidyl-lysine acetylation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0009887; P:organ morphogenesis; IEA:Compara.
 GO:0043923; P:positive regulation by host of viral transcription; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0060765; P:regulation of androgen receptor signaling pathway; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0007519; P:skeletal muscle tissue development; IEA:Compara.
 GO:0001756; P:somitogenesis; IEA:Compara. 
Interpro
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR010303; DUF902_CREBbp.
 IPR013178; Histone_H3-K56_AcTrfase_RTT109.
 IPR003101; KIX_dom.
 IPR009110; Nuc_rcpt_coact.
 IPR014744; Nuc_rcpt_coact_CREBbp.
 IPR000197; Znf_TAZ.
 IPR000433; Znf_ZZ. 
Pfam
 PF00439; Bromodomain
 PF09030; Creb_binding
 PF06001; DUF902
 PF08214; KAT11
 PF02172; KIX
 PF02135; zf-TAZ
 PF00569; ZZ 
SMART
 SM00297; BROMO
 SM00551; ZnF_TAZ
 SM00291; ZnF_ZZ 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50952; KIX
 PS50134; ZF_TAZ
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2 
PRINTS
 PR00503; BROMODOMAIN.