UniProt Accession

 H0YL33_HUMAN; H0YL33 

Genbank Protein ID

 AC087385 

Genbank Nucleotide ID

  

Protein Name

 Annexin 

Protein Synonyms/Alias

  

Gene Name

 ANXA2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	QEINRVYKEMYKTDL	ubiquitination	[1]
40	MYKTDLEKDIISDTS	ubiquitination	[1]
52	DTSGDFRKLMVALAK	ubiquitination	[1]
59	KLMVALAKGRRAEDG	ubiquitination	[1]
87	DLYDAGVKRKGTDVP	ubiquitination	[1, 2]
95	RKGTDVPKWISIMTE	ubiquitination	[1]
110	RSVPHLQKVFDRYKS	ubiquitination	[1]
116	QKVFDRYKSYSPYDM	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0005769; C:early endosome; IEA:Compara.
 GO:0019897; C:extrinsic to plasma membrane; IEA:Compara.
 GO:0035749; C:myelin sheath adaxonal region; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Compara.
 GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0007589; P:body fluid secretion; IEA:Compara.
 GO:0071229; P:cellular response to acid; IEA:Compara.
 GO:0030199; P:collagen fibril organization; IEA:Compara.
 GO:0042730; P:fibrinolysis; IEA:Compara.
 GO:0051099; P:positive regulation of binding; IEA:Compara. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002389; AnnexinII. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00198; ANNEXINII.