CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032472
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dedicator of cytokinesis 8 
Protein Synonyms/Alias
  
Gene Name
 Dock8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1357VSNQVLQKSRDVKAKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2100 AA 
Protein Sequence
MATLPSAERR AFALKINRYS SSEIRKQFTL PPNLGQYHRH SISTSGFPSL QLPQLYEPVE 60
PVDFEGLVMT HLNSLDAELA QELGDLTDDD LHVAFTPKEC RTLQHSLPEE GVELDPHVRD 120
CVQTYIREWL IVNRKNQGSS EFCSFKKTGS RRDFQKTLQK QTFESETLEC SEPDTQTGPR 180
HPLNVLCDVS GKGPLTSCDF DLRSLQPDER LENLLQLVSA EDFEKEKEEA RKTNRPAELF 240
ALYPPVDEED AVEIRPVPEC PKEHLGNRIL VKVLTLKFEI EIEPLFASIA LYDVKERKKI 300
SENFHCDLNS DQFKGFLRAH TPSIDPSSQA RSAVFSVTYP SSDIYLVVKI EKVLQQGEIA 360
DCAEPYMIIK ESDGGKSKEK VEKLKLQAES FCQRLGKYRM PFAWAPISLA SFFNISTLER 420
ESTDVEPGVG RNSVGEKRSL SQSRRPSERT LSLEENGVGS NFKATTLATN IFFKQEGDRL 480
SDEDLFKFLA DYKRSSSLQR RVKSIPGSLR LEISPAPDVM NCCLTPEMLP VKPFPENRTR 540
PHKEILEFPI REVYVPHTVY RNLLYVYPQR LNFASKLASA RNITIKIQFM CGEDPSNAMP 600
VIFGKSSGPE FLQEVYTAIT YHNKSPDFYE EVKIKLPAKL TVNHHLLFTF YHISCQQKQG 660
ASGESLLGYS WLPILLNERL QTGSYCLPVA LEKLPPNYSI HSAEKVPLQN PPIKWAEGHK 720
GVFNIEVQAV SSVHTQDNHL EKFFTLCHSL ESQVSFPIRV LDQKITESTL EHELKLSIIC 780
LNSSRLEPLV LFLHLVLDKL FQLSVQPMVI AGQTANFSQF AFESVVAIAN SLHNSKDLRK 840
DQHGRNCLLA SYVHYVFRLP ELHRDTSKSG GPITVVPDPR YHTYGRTSAA AVSSKLMQAR 900
VMSSSNPDLT GSHCAADEEV KNIMSSKIAD RNCSRMSYYC SGNSDAPGST AAPRPVSKKH 960
FHEELALQMV VSTGVVRETV FKYAWFFFEL LVKSMAQYVH NLDKRDSFRR TRFSDRFKDD 1020
ITTIVNVVTS EIAALLVKPQ KESEQAEKIN ISLAFFLYDL LSIMDRGFVF NLIKHYCSQL 1080
SAKLNILPTL ISMRLEFLRI LCSHEHYLNL NLLFMNTDTA PASPCPSISS QNSSSCSSFQ 1140
DQKIASMFDL TPEYRQQHFL TGLLFTELAV ALDAEGDGIS RVQRKAVSAI HSLLCSHDLD 1200
PRCRKPEVKV KIAALYLPLV GIILDALPQL YDFTDARSGR SRASGSYEEQ DVANGINQNV 1260
ALAIAGNHFN LKTSGAMLSS LPYKQYNMLN ADTTRHLMIC FLWIMKNADQ SLIRKWIADL 1320
PSMQLNRILD LLFICVSCFE YKGKQSSDKV SNQVLQKSRD VKAKLEEALL RGEGARGEMM 1380
RRRIPGTDRF PGINENLRWR KEQTQWRQAN EKLDKTKAEL DQEALISGNL ATEANLIILD 1440
MQENIIQASS ALDCKDSLLG GVLRVLVNSL SCDQSTTYLT HCFATLRALI AKFGDLLFEE 1500
EMEQCADLCQ RVLHHCSSSM DVTRSQACAT LYLLMRFSFG ATSNFARVKM QVTMALASLV 1560
GKAPDFNEEH LRRSLRTILA YSEEDTAMQT TPFPMQVEEL LCNLNSILYD TVKMREFQED 1620
PEMLMDLMYR IAKSYQASPD LRLTWLQNMA EKHTKKKCFT EAAMCLVHAA ALVAEYLSML 1680
EDHSYLPVGS VSFQNISSNV LEESAVSDDT LSPDEDGVCS GRYFTESGLV GLLEQAAELF 1740
STGGLYETVN EVYKLVIPIL EAHRDFRKLT STHDKLQKAF DNIINKDHKR MFGTYFRVGF 1800
YGSRFGDLDE QEFVYKEPAI TKLPEISHRL EGFYGQCFGA EFVEVIKDST PVDKTKLDPN 1860
KAYIQITFVE PYFDEYEMKD RVTYFEKNFN LRRFMYTTPF TLEGRPRGEL HEQHRRNTVL 1920
TTMHAFPYIK TRIRVSQKEE FVLTPIEVAI EDMKKKTLQL AVATHQEPPD AKMLQMVLQG 1980
SVGATVNQGP LEVAQVFLAE IPADPKLYRH HNKLRLCFKE FIMRCGEAVE KNRRLITAEQ 2040
REYQQELKKN YNKLRDSLRP MIERKIPELY KPIFRVDSQK RDSFHRSSFR KCETQLSQGS 2100 
Gene Ontology
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR021816; DOCK_C/D_N.
 IPR026798; DOCK_C_fam. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF11878; DUF3398 
SMART
  
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2 
PRINTS