CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029731
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Annexin A2 
Protein Synonyms/Alias
  
Gene Name
 Anxa2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
81QEINRVYKEMYKTDLacetylation[1]
81QEINRVYKEMYKTDLubiquitination[2]
85RVYKEMYKTDLEKDIacetylation[1, 3]
90MYKTDLEKDIISDTSacetylation[1, 3, 4]
102DTSGDFRKLMVALAKacetylation[5]
109KLMVALAKGRRAEDGacetylation[1, 4]
145RKGTDVPKWISIMTEacetylation[1]
160RSVCHLQKVFERYKSacetylation[1, 3, 4, 5, 6, 7]
166QKVFERYKSYSPYDMacetylation[1, 3]
166QKVFERYKSYSPYDMsuccinylation[3]
178YDMLESIKKEVKGDLacetylation[1, 4]
212DRLYDSMKGKGTRDKacetylation[4]
235RSEVDMLKIRSEFKRacetylation[1, 4]
235RSEVDMLKIRSEFKRubiquitination[2]
243IRSEFKRKYGKSLYYacetylation[1]
246EFKRKYGKSLYYYIQacetylation[1, 3, 4]
257YYIQQDTKGDYQKALacetylation[1]
257YYIQQDTKGDYQKALubiquitination[2]
262DTKGDYQKALLYLCGacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [6] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [7] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599
Functional Description
  
Sequence Annotation
  
Keyword
 Annexin; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 272 AA 
Protein Sequence
IKEKEKQLLF SKACRFCPCP PGCCFLWLPP APPQSVAGPK FGFGPKISNA VQGLGTDEDS 60
LIEIICSRTN QELQEINRVY KEMYKTDLEK DIISDTSGDF RKLMVALAKG RRAEDGSVID 120
YELIDQDARE LYDAGVKRKG TDVPKWISIM TERSVCHLQK VFERYKSYSP YDMLESIKKE 180
VKGDLENAFL NLVQCIQNKP LYFADRLYDS MKGKGTRDKV LIRIMVSRSE VDMLKIRSEF 240
KRKYGKSLYY YIQQDTKGDY QKALLYLCGG DD 272 
Gene Ontology
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0019897; C:extrinsic to plasma membrane; IDA:MGI.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
 GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0071229; P:cellular response to acid; IDA:MGI.
 GO:0030199; P:collagen fibril organization; IMP:MGI.
 GO:0042730; P:fibrinolysis; IMP:MGI.
 GO:0051099; P:positive regulation of binding; IMP:MGI. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002389; AnnexinII. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.
 PR00198; ANNEXINII.