UniProt Accession

 NDUV1_HUMAN; P49821; O60924; O60940; Q16104; Q6IBR3; Q96BF8; Q96HS7 

Genbank Protein ID

 Y17379; Y17380; Y17381; Y17382; Y17383; AF053069; AF053070; AF092131; CR456739; CH471076; BC008146; BC015645; AH004147; S67973 

Genbank Nucleotide ID

 CAA76757.1; CAA76757.1; CAA76757.1; CAA76757.1; CAA76757.1; AAC39750.1; AAC39722.1; AAD40373.1; CAG33020.1; EAW74655.1; AAH08146.1; AAH15645.1; AAB24883.1; AAB29698.2 

Protein Name

 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 

Protein Synonyms/Alias

 Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit 

Gene Name

 NDUFV1 

Gene Synonyms/Alias

 UQOR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	RGDWYKTKEILLKGP	ubiquitination	[1]
62	KTKEILLKGPDWILG	ubiquitination	[1]
72	DWILGEIKTSGLRGR	ubiquitination	[1]
385	EGVDWMNKVMARFVR	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 

Sequence Annotation

 NP_BIND 87 96 NAD(H) (By similarity).
 NP_BIND 199 247 FMN (By similarity).
 METAL 379 379 Iron-sulfur (4Fe-4S) (Potential).
 METAL 382 382 Iron-sulfur (4Fe-4S) (Potential).
 METAL 385 385 Iron-sulfur (4Fe-4S) (Potential).
 METAL 425 425 Iron-sulfur (4Fe-4S) (Potential).
 MOD_RES 81 81 N6-acetyllysine (By similarity).
 MOD_RES 104 104 N6-acetyllysine (By similarity).
 MOD_RES 375 375 N6-acetyllysine (By similarity).  

Keyword

 4Fe-4S; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Electron transport; Flavoprotein; FMN; Iron; Iron-sulfur; Leigh syndrome; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Polymorphism; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 464 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR001949; NADH-UbQ_OxRdtase_51kDa_CS.
 IPR019575; NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
 IPR011537; NADH-UbQ_OxRdtase_suF.
 IPR011538; NADH_UbQ_OxRdtase_51kDa_su.
 IPR019554; Soluble_ligand-bd. 

Pfam

 PF01512; Complex1_51K
 PF10589; NADH_4Fe-4S
 PF10531; SLBB 

SMART

 SM00928; NADH_4Fe-4S 

PROSITE

 PS00644; COMPLEX1_51K_1
 PS00645; COMPLEX1_51K_2 

PRINTS