UniProt Accession

 ATG19_YEAST; P35193; D6W1Y6; Q6B1A6 

Genbank Protein ID

 X75449; X83121; Z74824; AY693174; BK006948 

Genbank Nucleotide ID

 CAA53201.1; CAA58199.1; CAA99094.1; AAT93193.1; DAA10702.1 

Protein Name

 Autophagy-related protein 19 

Protein Synonyms/Alias

 Cytoplasm-to-vacuole targeting protein 19 

Gene Name

 ATG19 

Gene Synonyms/Alias

 CVT19; YOL082W; O0980; YOL01 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
216	FTELKTVKQLEDVFQ	ubiquitination	[1]
238	LSQECDSKTEIASDH	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Plays also a role in regulation of filamentous growth. 

Sequence Annotation

 REGION 21 28 ATG11-binding.
 REGION 254 367 AMS1-binding.
 REGION 406 415 ATG8-binding.
 MOTIF 412 415 WXXL.
 MOD_RES 136 136 Phosphoserine.
 MOD_RES 141 141 Phosphoserine.
 CROSSLNK 213 213 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 216 216 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Autophagy; Coiled coil; Complete proteome; Isopeptide bond; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 415 AA 

Protein Sequence

Gene Ontology

 GO:0019898; C:extrinsic to membrane; IDA:SGD.
 GO:0000407; C:pre-autophagosomal structure; IDA:SGD.
 GO:0034045; C:pre-autophagosomal structure membrane; IEA:UniProtKB-SubCell.
 GO:0030674; F:protein binding, bridging; IMP:SGD.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0032258; P:CVT pathway; IMP:SGD.
 GO:0030433; P:ER-associated protein catabolic process; IMP:SGD.
 GO:0031503; P:protein complex localization; IMP:SGD.
 GO:0016485; P:protein processing; IMP:SGD.
 GO:0016050; P:vesicle organization; IMP:SGD. 

Interpro

 IPR024543; Atg19/Atg34_C. 

Pfam

 PF12744; ATG19_autophagy 

SMART

  

PROSITE

  

PRINTS