| Tag | Content |
|---|
| CPLM ID | CPLM-024354 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 |
Protein Synonyms/Alias | Phosphoinositide phospholipase C-eta-2; Phosphoinositide phospholipase C-like 4; PLC-L4; Phospholipase C-like protein 4; Phospholipase C-eta-2; PLC-eta2 |
Gene Name | Plch2 |
Gene Synonyms/Alias | Plcl4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 479 | DVIETINKYAFIKNE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. |
Sequence Annotation | DOMAIN 121 229 PH.
DOMAIN 243 278 EF-hand 1.
DOMAIN 279 315 EF-hand 2.
DOMAIN 400 545 PI-PLC X-box.
DOMAIN 707 821 PI-PLC Y-box.
DOMAIN 826 933 C2.
REGION 75 229 Necessary for plasma membrane
ACT_SITE 415 415 By similarity.
ACT_SITE 459 459 By similarity.
METAL 416 416 Calcium 1; catalytic (By similarity).
METAL 445 445 Calcium 1; catalytic (By similarity).
METAL 447 447 Calcium 1; catalytic (By similarity).
METAL 494 494 Calcium 1; catalytic (By similarity).
METAL 865 865 Calcium 2; via carbonyl oxygen (By
METAL 867 867 Calcium 2 (By similarity).
METAL 891 891 Calcium 2 (By similarity).
METAL 920 920 Calcium 3 (By similarity).
METAL 921 921 Calcium 3; via carbonyl oxygen (By
METAL 922 922 Calcium 3 (By similarity).
BINDING 543 543 Substrate (By similarity).
BINDING 545 545 Substrate (By similarity).
BINDING 734 734 Substrate (By similarity).
BINDING 761 761 Substrate (By similarity).
MOD_RES 676 676 Phosphoserine.
MOD_RES 686 686 Phosphoserine. |
Keyword | Alternative splicing; Calcium; Cell membrane; Complete proteome; Cytoplasm; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Transducer. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1501 AA |
Protein Sequence | MGGLAWGPSR AAGSSWVNAS GTWEQPLRGF SGLQGGRRRG RGEKGIPEEP LCQLTPQLGL 60
SLRVPFGLGD YGLDMPGPQP SAASQTTGAV ACLAEVLLWV GGSVVVSPRW QLSLVVERCM 120
SAMQEGTQMV KLRGSSKGLV RFYYLDEHRS CLRWRPSRKN EKAKISIDSI QEVSEGRQSE 180
IFQRYPDSSF DPNCCFSIYH GSHRESLDLV SPSSEEARTW VTGLRYLMAG ISDEDSLARR 240
QRTRDQWLKQ TFDEADKNGD GSLSISEVLQ LLHKLNVNLP RQRVKQMFRE ADTDDHQGTL 300
GFEEFCAFYK MMSTRRDLYL LMLTYSNHKD HLDASDLQRF LEVEQKMNGV TLESCQNIIE 360
QFEPCLENKS KGMLGIDGFT NYTRSPAGDI FNPEHNRVHQ DMTQPLSHYF ITSSHNTYLV 420
GDQLMSQSRV DMYAWVLQAG CRCVEVDCWD GPDGEPIVHH GYTLTSKILF KDVIETINKY 480
AFIKNEYPVI LSIENHCSVV QQKKMAQYLT DILGDKLDLS SVSSEDATML PSPQMLKGKI 540
LVKGKKLPAN ISEDAEEGEV SDEDSADEME DDCKLLNGDA STNRKRVENI AKKKLDSLIK 600
ESKIRDCEDP NDFSVSTLSP SGKLGRKAEA KKGQSKVEED VEAGEDSGVS RQNSRLFMSS 660
FSKRKKKGSK IKKVASVEEG DETLDSPGSQ SRGTARQKKT MKLSRALSDL VKYTKSVGTH 720
DVEIEVVSSW QVSSFSETKA HQILQQKPTQ YLRFNQHQLS RIYPSSYRVD SSNYNPQPFW 780
NAGCQMVALN YQSEGRMLQL NRAKFSANGD CGYVLKPQCM CQGVFNPNSE DPLPGQLKKQ 840
LALRIISGQQ LPKPRDSVLG DRGEIIDPFV EVEVIGLPVD CSKEQTRVVD DNGFNPMWEE 900
TLVFTVHMPE IALVRFLVWD HDPIGRDFIG QRTLAFSSIM PGYRHVYLEG MEEASIFVHV 960
AVSDISGKVK QTLGLKGLFL RGTKPGSLDS HAAGQPLPRP SVSQRLLRRT ASAPTKSQKP 1020
SRKGFPELAL GTQDAGSEGA ADDVAPSSPN PALEAPTQER SGSSSPRGKA PGGEATEERT 1080
LAQVRSPNAP EGPGPAGMAA TCMKCVVGSC AGMDVEGLRR EQQPSPGPAG SHMAISHQPR 1140
ARVDSLGGPC CSPSPRATPG RSKEAPKGPR ARRQGPGGGS VSSDSSSPDS PGSPKVAPCQ 1200
PEGAHRQQGA LQGEMNALFV QKLEEIRSHS PMFSTVRD 1238 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IDA:MGI. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC. GO:0004629; F:phospholipase C activity; IDA:MGI. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. GO:0046488; P:phosphatidylinositol metabolic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |