CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020752
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ES1 protein homolog, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 D10Jhu81e 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
92MHVIDHTKGEPSEREacetylation[1]
139PGGFGAAKNLSTFAVacetylation[1]
149STFAVDGKDCKVNKEacetylation[1, 2, 3, 4]
152AVDGKDCKVNKEVERacetylation[1, 4]
155GKDCKVNKEVERVLKacetylation[2, 3, 4]
162KEVERVLKEFHGAKKacetylation[1, 3, 4, 5, 6]
162KEVERVLKEFHGAKKsuccinylation[6]
169KEFHGAKKPIGLCCIacetylation[5]
186VLAAKVIKGVEVTVGacetylation[1, 2]
201HEQEEGGKWPYAGTAacetylation[1, 2, 3, 4, 6, 7, 8, 9, 10, 11]
201HEQEEGGKWPYAGTAsuccinylation[6]
217AIKALGAKHCVKGVTacetylation[1, 3, 4, 6, 12]
221LGAKHCVKGVTEAHVacetylation[1, 3, 4, 6]
221LGAKHCVKGVTEAHVsuccinylation[6]
231TEAHVDQKNKVVTTPacetylation[1, 2, 3, 4, 6]
231TEAHVDQKNKVVTTPsuccinylation[6]
266NVLELTGK*******acetylation[4]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [7] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [8] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [9] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [10] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [11] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [12] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647
Functional Description
  
Sequence Annotation
 MOD_RES 217 217 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Mitochondrion; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 266 AA 
Protein Sequence
MAAVRVLVAP RLASALLPLS RYHRAPSQRA ALHSSAPRPG ARVALVLSGC GVYDGTEIHE 60
ASAILVHLSR GGAEVQIFAP DVPQMHVIDH TKGEPSERES RNVLAESARI ARGKITSLAQ 120
LNAANHDAAI FPGGFGAAKN LSTFAVDGKD CKVNKEVERV LKEFHGAKKP IGLCCIAPVL 180
AAKVIKGVEV TVGHEQEEGG KWPYAGTAEA IKALGAKHCV KGVTEAHVDQ KNKVVTTPAF 240
MCETALHHIH DGIGAMVKNV LELTGK 266 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI. 
Interpro
 IPR002818; ThiJ/PfpI. 
Pfam
 PF01965; DJ-1_PfpI 
SMART
  
PROSITE
  
PRINTS