UniProt Accession

 MENH_ECOLI; P37355; P76477; P76932 

Genbank Protein ID

 L35030; U00096; AP009048; M93421 

Genbank Nucleotide ID

 AAA24151.1; AAC75323.1; BAA16087.2 

Protein Name

 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase 

Protein Synonyms/Alias

 SHCHC synthase 

Gene Name

 menH 

Gene Synonyms/Alias

 yfbB; b2263; JW2258 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
212	LCGERDSKFRALAAE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Lyase; Menaquinone biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0070205; F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity; IDA:EcoCyc.
 GO:0009234; P:menaquinone biosynthetic process; IDA:EcoCyc. 

Interpro

 IPR022485; SHCHC_synthase_MenH. 

Pfam

  

SMART

  

PROSITE

  

PRINTS