CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005334
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peptidyl-prolyl cis-trans isomerase 
Protein Synonyms/Alias
 PPIase; Cyclophilin; Cyclosporin A-binding protein; Rotamase 
Gene Name
 Cyp1 
Gene Synonyms/Alias
 Cyp-1; CG9916 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
94LRSDVVPKTAENFRAacetylation[1]
107RALCTGEKGFGYKGSacetylation[1]
112GEKGFGYKGSIFHRVacetylation[1]
145GKSIYGNKFPDENFEacetylation[1]
181QFFICTVKTAWLDNKacetylation[1]
214SYGSQSGKTSKKIIVacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 
Sequence Annotation
 DOMAIN 70 226 PPIase cyclophilin-type.
 MOD_RES 158 158 Phosphoserine.  
Keyword
 Complete proteome; Cyclosporin; Cytoplasm; Direct protein sequencing; Isomerase; Phosphoprotein; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 227 AA 
Protein Sequence
MVSFCATLIR QFRHRSAAAF QIAESAILAN KSITLASSAC SVNRGQLQFG IQIVREYSKA 60
SKMSTLPRVF FDMTADNEPL GRIVMELRSD VVPKTAENFR ALCTGEKGFG YKGSIFHRVI 120
PNFMCQGGDF TNHNGTGGKS IYGNKFPDEN FELKHTGSGI LSMANAGANT NGSQFFICTV 180
KTAWLDNKHV VFGEVVEGLD VVKKIESYGS QSGKTSKKII VANSGSL 227 
Gene Ontology
 GO:0005829; C:cytosol; ISS:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0042277; F:peptide binding; IEA:UniProtKB-KW.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; ISS:FlyBase.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0035071; P:salivary gland cell autophagic cell death; IEP:FlyBase. 
Interpro
 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS. 
Pfam
 PF00160; Pro_isomerase 
SMART
  
PROSITE
 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 
PRINTS
 PR00153; CSAPPISMRASE.