| Tag | Content |
|---|
| CPLM ID | CPLM-023270 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 12 member 4 |
Protein Synonyms/Alias | Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; hKCC1 |
Gene Name | SLC12A4 |
Gene Synonyms/Alias | KCC1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 85 | KVSSLLGKLVSYTNL | ubiquitination | [1] | | 988 | QMTWTRDKYMTETWD | ubiquitination | [1] | | 1010 | FRELVHIKPDQSNVR | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity. |
Sequence Annotation | MOD_RES 47 47 Phosphoserine (By similarity).
MOD_RES 51 51 Phosphoserine.
MOD_RES 967 967 Phosphoserine.
MOD_RES 983 983 Phosphothreonine (By similarity).
CARBOHYD 245 245 N-linked (GlcNAc...) (Potential).
CARBOHYD 312 312 N-linked (GlcNAc...) (Potential).
CARBOHYD 331 331 N-linked (GlcNAc...) (Potential).
CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
CARBOHYD 439 439 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1085 AA |
Protein Sequence | MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL SPLEASRGID 60
YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE EAESGEGTRR RAAEAPSMGT 120
LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV LQALLIVLIC CCCTLLTAIS MSAIATNGVV 180
PAGGSYFMIS RSLGPEFGGA VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGA 240
HDTSNATLNN MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYAGGIKSIF 300
DPPVFPVCML GNRTLSRDQF DICAKTAVVD NETVATQLWS FFCHSPNLTT DSCDPYFMLN 360
NVTEIPGIPG AAAGVLQENL WSAYLEKGDI VEKHGLPSAD APSLKESLPL YVVADIATSF 420
TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS IPVGTILAII TTSLVYFSSV VLFGACIEGV 480
VLRDKYGDGV SRNLVVGTLA WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP 540
FLRVFGHGKV NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT 600
LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMLIAGMIYK YIEYQGAEKE 660
WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL DEDLHVKYPR LLTFASQLKA 720
GKGLTIVGSV IQGSFLESYG EAQAAEQTIK NMMEIEKVKG FCQVVVASKV REGLAHLIQS 780
CGLGGMRHNS VVLGWPYGWR QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER 840
YLEGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQMDDNSIQ MKKDLAVFLY 900
HLRLEAEVEV VEMHNSDISA YTYERTLMME QRSQMLRQMR LTKTEREREA QLVKDRHSAL 960
RLESLYSDEE DESAVGADKI QMTWTRDKYM TETWDPSHAP DNFRELVHIK PDQSNVRRMH 1020
TAVKLNEVIV TRSHDARLVL LNMPGPPRNS EGDENCIPLW RGRQLGGG 1068 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0015379; F:potassium:chloride symporter activity; TAS:ProtInc. GO:0006884; P:cell volume homeostasis; TAS:ProtInc. GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |