UniProt Accession

 D3Z4U1_MOUSE; D3Z4U1 

Genbank Protein ID

 AC114618; AC141632; CH466532 

Genbank Nucleotide ID

 EDL11965.1 

Protein Name

 Uricase 

Protein Synonyms/Alias

  

Gene Name

 Uox 

Gene Synonyms/Alias

 mCG_11801 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
45	YVEEVPWKRFEKNGI	acetylation	[1, 2, 3]
45	YVEEVPWKRFEKNGI	succinylation	[2]
45	YVEEVPWKRFEKNGI	ubiquitination	[4]
49	VPWKRFEKNGIKHVH	acetylation	[1, 3, 5]
53	RFEKNGIKHVHAFIH	acetylation	[3]
85	PVIHSGIKDLKVLKT	acetylation	[3]
85	PVIHSGIKDLKVLKT	ubiquitination	[4]
88	HSGIKDLKVLKTTQS	acetylation	[3]
91	IKDLKVLKTTQSGFE	acetylation	[1]
91	IKDLKVLKTTQSGFE	ubiquitination	[4]
102	SGFEGFLKDQFTTLP	acetylation	[1, 3, 6]
102	SGFEGFLKDQFTTLP	ubiquitination	[4]
112	FTTLPEVKDRCFATQ	acetylation	[1, 2, 3, 6]
112	FTTLPEVKDRCFATQ	succinylation	[2]
112	FTTLPEVKDRCFATQ	ubiquitination	[4]
123	FATQVYCKWRYQRRD	acetylation	[3]
123	FATQVYCKWRYQRRD	ubiquitination	[4]
147	VRDIVLQKFAGPYDK	acetylation	[1, 2, 3, 6]
147	VRDIVLQKFAGPYDK	succinylation	[2]
147	VRDIVLQKFAGPYDK	ubiquitination	[4]
154	KFAGPYDKGEYSPSV	acetylation	[1, 2, 3, 5, 6]
154	KFAGPYDKGEYSPSV	succinylation	[2]
154	KFAGPYDKGEYSPSV	ubiquitination	[4]
163	EYSPSVQKTLYDIQV	acetylation	[3]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [6] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199] 

Functional Description

 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Oxidoreductase; Purine metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 199 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; TAS:MGI.
 GO:0004846; F:urate oxidase activity; TAS:MGI.
 GO:0006144; P:purine nucleobase metabolic process; TAS:MGI. 

Interpro

 IPR002042; Uricase.
 IPR019842; Uricase_CS. 

Pfam

 PF01014; Uricase 

SMART

  

PROSITE

 PS00366; URICASE 

PRINTS

 PR00093; URICASE.