| Tag | Content |
|---|
| CPLM ID | CPLM-009939 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Plexin-A2 |
Protein Synonyms/Alias | Plex 2; Plexin-2 |
Gene Name | Plxna2 |
Gene Synonyms/Alias | Kiaa0463 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1415 | LLSDLIDKNLENKNH | ubiquitination | [1] | | 1802 | SNKLLYAKDIPSYKN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. |
Sequence Annotation | DOMAIN 35 508 Sema.
DOMAIN 858 951 IPT/TIG 1.
DOMAIN 954 1037 IPT/TIG 2.
DOMAIN 1041 1139 IPT/TIG 3.
DOMAIN 1143 1228 IPT/TIG 4.
MOD_RES 1432 1432 Phosphoserine.
MOD_RES 1630 1630 Phosphoserine.
MOD_RES 1633 1633 Phosphoserine.
CARBOHYD 15 15 N-linked (GlcNAc...) (Potential).
CARBOHYD 76 76 N-linked (GlcNAc...).
CARBOHYD 163 163 N-linked (GlcNAc...).
CARBOHYD 327 327 N-linked (GlcNAc...).
CARBOHYD 598 598 N-linked (GlcNAc...).
CARBOHYD 696 696 N-linked (GlcNAc...) (Potential).
CARBOHYD 756 756 N-linked (GlcNAc...) (Potential).
CARBOHYD 1180 1180 N-linked (GlcNAc...) (Potential).
CARBOHYD 1205 1205 N-linked (GlcNAc...) (Potential).
DISULFID 94 103
DISULFID 129 137
DISULFID 284 405
DISULFID 300 356
DISULFID 374 393
DISULFID 511 528
DISULFID 517 559
DISULFID 520 537
DISULFID 531 543
DISULFID 594 613 |
Keyword | 3D-structure; Cell membrane; Coiled coil; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1894 AA |
Protein Sequence | MEQRRFYLRA MQADNLSVVL LSVAWLLLAR GTTGMPQYST FHSENRDWTF NHLTVHRRTG 60
AVYVGAINRV YKLTGNLTIQ VAHKTGPEED NKACYPPLIV QPCSEVLTLT NNVNKLLIID 120
YSENRLLACG SLYQGVCKLL RLDDLFILVE PSHKKEHYLS SVNKTGTMYG VIVRSEGEDG 180
KLFIGTAVDG KQDYFPTLSS RKLPRDPESS AMLDYELHSD FVSSLIKIPS DTLALVSHFD 240
IFYIYGFASG GFVYFLTVQP ETPDGMAINS AGDLFYTSRI VRLCKDDPKF HSYVSLPFGC 300
TRAGVEYRLL QAAYLAKPGE ALAQAFNISS DEDVLFAIFS KGQKQYHHPP DDSALCAFPI 360
RAINLQIKER LQSCYHGEGN LELNWLLGKD VQCTKAPVPI DDNFCGLDIN QPLGGSTPVE 420
GLTLYTTSRD RLTSVASYVY NGYSVVFVGT KSGKLKKIRA DGPPHGGVQY EMVSVFKDGS 480
PILRDMAFSI NQLYLYVMSE RQVTRVPVES CEQYTTCGEC LSSGDPHCGW CALHNMCSRR 540
DKCQRAWEAN RFAASISQCM SLEVHPNSIS VSDHSRLLSL VVNDAPNLSE GIACAFGNLT 600
EVEGQVSGSQ VICISPGPKD VPVIPLDQDW FGLELQLRSK ETGKIFVSTE FKFYNCSAHQ 660
LCLSCVNSAF RCHWCKYRNL CTHDPTTCSF QEGRINVSED CPQLVPTEEI LIPVGEVKPI 720
TLKARNLPQP QSGQRGYECV LSIQGAVHRV PALRFNSSSV QCQNSSYQYD GMDISNLAVD 780
FAVVWNGNFI IDNPQDLKVH LYKCAAQRES CGLCLKADHK FECGWCSGER RCTLHQHCPS 840
TSSPWLDWSS HNVKCSNPQI TEILTVSGPP EGGTRVTIHG VNLGLDFSEI AHHVQVAGVP 900
CTPIPGEYII AEQIVCEMGH AVIGTTSGPV RLCIGECKPE FMTKSHQQYT FVNPSVLSLS 960
PIRGPESGGT MVTITGHYLG AGSSVAVYLG NQTCEFYGRS MNEIVCVSPP SSNGLGPVPV 1020
SVSVDRARVD SSLQFEYIDD PRVQRIEPEW SITSGHTPLT ITGFNLDVIQ EPRVRVKFNG 1080
KESVNVCTVV NTTTLTCLAP SLTSDYRPGL DTVERPDEFG FLFNNVQSLL IYNDTKFIYY 1140
PNPTFELLSP TGILDQKPGS PIILKGKNLC PPASGGAKLN YTVMIGETPC TVTVSETQLL 1200
CEPPNLTGQH KVMVHVGGMV FSPGSVSVIS DSLLTLPAII SIAAGGSLLL IIVIIVLIAY 1260
KRKSRENDLT LKRLQMQMDN LESRVALECK EAFAELQTDI NELTSDLDRS GIPYLDYRTY 1320
AMRVLFPGIE DHPVLRELEV QGNGQQHVEK ALKLFAQLIN NKVFLLTFIR TLELQRSFSM 1380
RDRGNVASLI MTGLQGRLEY ATDVLKQLLS DLIDKNLENK NHPKLLLRRT ESVAEKMLTN 1440
WFAFLLHKFL KECAGEPLFM LYCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIEYKTL 1500
ILNCVNPDNE NSPEIPVKVL NCDTITQVKE KILDAVYKNV PYSQRPRAVD MDLEWRQGRI 1560
ARVVLQDEDI TTKIEGDWKR LNTLMHYQVS DRSVVALVPK QTSSYNIPAS ASISRTSISR 1620
YDSSFRYTGS PDSLRSRVPM ITPDLESGVK VWHLVKNHDH GDQKEGDRGS KMVSEIYLTR 1680
LLATKGTLQK FVDDLFETLF STVHRGSALP LAIKYMFDFL DEQADRHSIH DTDVRHTWKS 1740
NCLPLRFWVN VIKNPQFVFD IHKGSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY 1800
AKDIPSYKNW VERYYADIAK LPAISDQDMN AYLAEQSRLH ATEFNMLSAL NEIYSYVSKY 1860
SEELIGALEQ DEQARRQRLA YKVEHLINAM SIES 1894 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:UniProtKB. GO:0005622; C:intracellular; IEA:InterPro. GO:0017154; F:semaphorin receptor activity; IMP:UniProtKB. GO:0051642; P:centrosome localization; IMP:MGI. GO:0021935; P:cerebellar granule cell precursor tangential migration; IMP:MGI. GO:0060174; P:limb bud formation; IEP:BHF-UCL. GO:0021915; P:neural tube development; IEP:BHF-UCL. GO:0060037; P:pharyngeal system development; IEP:BHF-UCL. GO:0030334; P:regulation of cell migration; IMP:UniProtKB. GO:0001756; P:somitogenesis; IEP:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |