CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013684
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Torsin-1A-interacting protein 1 
Protein Synonyms/Alias
 Lamin-associated protein 1B; LAP1B 
Gene Name
 TOR1AIP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
174DLSQTISKKTVRSIQubiquitination[1]
211EATSVQQKVNFSEEGubiquitination[2]
236HSSVTTVKARSRDSDubiquitination[1, 2]
308MQNDSILKSELGNQSubiquitination[2, 3, 4, 5]
334PQNASFVKRNRWWLLubiquitination[3, 5]
556YNHMDPDKLNGLWSRubiquitination[3, 5, 6]
578VQPENALKRGICL**ubiquitination[5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina (By similarity). 
Sequence Annotation
 MOD_RES 60 60 Phosphoserine (By similarity).
 MOD_RES 135 135 Phosphoserine.
 MOD_RES 143 143 Phosphoserine.
 MOD_RES 154 154 Phosphoserine.
 MOD_RES 156 156 Phosphoserine.
 MOD_RES 157 157 Phosphoserine.
 MOD_RES 186 186 Phosphoserine.
 MOD_RES 215 215 Phosphoserine.
 MOD_RES 220 220 Phosphothreonine.
 MOD_RES 227 227 Phosphoserine.
 MOD_RES 239 239 Phosphoserine (By similarity).
 MOD_RES 245 245 Phosphoserine (By similarity).
 MOD_RES 305 305 Phosphoserine.
 MOD_RES 315 315 Phosphoserine.
 CARBOHYD 399 399 N-linked (GlcNAc...).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Glycoprotein; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 583 AA 
Protein Sequence
MAGDGRRAEA VREGWGVYVT PRAPIREGRG RLAPQNGGSS DAPAYRTPPS RQGRREVRFS 60
DEPPEVYGDF EPLVAKERSP VGKRTRLEEF RSDSAKEEVR ESAYYLRSRQ RRQPRPQETE 120
EMKTRRTTRL QQQHSEQPPL QPSPVMTRRG LRDSHSSEED EASSQTDLSQ TISKKTVRSI 180
QEAPVSEDLV IRLRRPPLRY PRYEATSVQQ KVNFSEEGET EEDDQDSSHS SVTTVKARSR 240
DSDESGDKTT RSSSQYIESF WQSSQSQNFT AHDKQPSVLS SGYQKTPQEW APQTARIRTR 300
MQNDSILKSE LGNQSPSTSS RQVTGQPQNA SFVKRNRWWL LPLIAALASG SFWFFSTPEV 360
ETTAVQEFQN QMNQLKNKYQ GQDEKLWKRS QTFLEKHLNS SHPRSQPAIL LLTAARDAEE 420
ALRCLSEQIA DAYSSFRSVR AIRIDGTDKA TQDSDTVKLE VDQELSNGFK NGQNAAVVHR 480
FESFPAGSTL IFYKYCDHEN AAFKDVALVL TVLLEEETLG TSLGLKEVEE KVRDFLKVKF 540
TNSNTPNSYN HMDPDKLNGL WSRISHLVLP VQPENALKRG ICL 583 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
 GO:0071763; P:nuclear membrane organization; IEA:Compara.
 GO:0034504; P:protein localization to nucleus; IEA:Compara. 
Interpro
 IPR008662; Lamina-ass_polypeptide_CLAP1C. 
Pfam
 PF05609; LAP1C 
SMART
  
PROSITE
  
PRINTS