CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039404
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Stat1 
Protein Synonyms/Alias
 Signal transducer and activator of transcription 1 
Gene Name
 Stat1 
Gene Synonyms/Alias
 rCG_22495 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
216KRKEIIHKIRELLNSacetylation[1]
379NTVKGFRKFNILGTHacetylation[1]
379NTVKGFRKFNILGTHubiquitination[2]
410EFRHLQLKEQKNAGNacetylation[1]
550CKENINDKNFSFWPWubiquitination[2]
592ERERALLKDQQPGTFubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 749 AA 
Protein Sequence
MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAAYDV SFATIRFHDL 60
LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPVQ MSMIIHNCLK EERKILENAQ 120
RFNQAQEGNI QNTVMLDKQK ELDSKVRNVK DQVMCIEHEI KTLEDLQDEY DFKCKTSQNR 180
ESEANGVAKS DQKQEQLLLH KMFLMLDNKR KEIIHKIREL LNSIELTQNT LINDELVEWK 240
RRQQSACIGG PPNACLDQLQ SWFTIVAESL QQVRQQLKKL EELEQKFTYE QDPITKNKQV 300
LSDRTFVLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK LQELNYNLKV 360
KVSFDKDVNE KNTVKGFRKF NILGTHTKVM NMEESTNGSL AAEFRHLQLK EQKNAGNRTN 420
EGPLIVTEEL HSLSFETQLC QPGLVIDLET TSLPVVVISN VSQLPSGWAS ILWYNMLVTE 480
PRNLSFFLNP PCAWWSQLSE VLSWQFSSVT KRGLNADQLS MLGEKLLGPN AGPDGLIPWT 540
RFCKENINDK NFSFWPWIDT ILELIKKHLL CLWNDGCIMG FISKERERAL LKDQQPGTFL 600
LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN YKVMAAENIP 660
ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDDPKRTG YIKTELISVS EVHPSRLQST 720
ENLLPMSPEE FDEMSKIVGS EFDSMMSAV 749 
Gene Ontology
 GO:0030424; C:axon; IDA:RGD.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0000983; F:RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:RGD.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0008015; P:blood circulation; IMP:RGD.
 GO:0032869; P:cellular response to insulin stimulus; IDA:RGD.
 GO:0035458; P:cellular response to interferon-beta; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IDA:RGD.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Compara.
 GO:0007259; P:JAK-STAT cascade; IMP:RGD.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
 GO:0016525; P:negative regulation of angiogenesis; IEA:Compara.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Compara.
 GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0061326; P:renal tubule development; IEA:Compara.
 GO:0051591; P:response to cAMP; IDA:RGD.
 GO:0034097; P:response to cytokine stimulus; IDA:RGD.
 GO:0042493; P:response to drug; IDA:RGD.
 GO:0043330; P:response to exogenous dsRNA; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
 GO:0009612; P:response to mechanical stimulus; IDA:RGD.
 GO:0007584; P:response to nutrient; IDA:RGD.
 GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Compara. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR008967; p53-like_TF_DNA-bd.
 IPR000980; SH2.
 IPR022752; STAT1_TAZ2-bd_C.
 IPR013800; STAT_TF_alpha.
 IPR015988; STAT_TF_coiled-coil.
 IPR001217; STAT_TF_core.
 IPR013801; STAT_TF_DNA-bd.
 IPR012345; STAT_TF_DNA-bd_sub.
 IPR013799; STAT_TF_prot_interaction. 
Pfam
 PF00017; SH2
 PF12162; STAT1_TAZ2bind
 PF01017; STAT_alpha
 PF02864; STAT_bind
 PF02865; STAT_int 
SMART
 SM00252; SH2
 SM00964; STAT_int 
PROSITE
 PS50001; SH2 
PRINTS